Hi Mutaz,
Matt Hutmacher described it well here:
https://www.cognigen.com/nmusers/2010-April/2448.html
A very brief summary of his excellent post is that subjects with a
combination of censored (BLQ) an uncensored (above the LLOQ and below the
ULOQ) will be biased in their reporting of CWRES
All,
Back in April 2010, Sebastian Bihorel and Martin Bergstrand initiated a
discussion regarding using the M3 and M4 methods for handling BQL data and
how it seemed to be a bug that NONMEM wouldn't compute WRES for the entire
set of subject data records whenever a BQL was included (
Our Client in the Boston area is looking for a strong PhD level scientist to
deliver mechanistic and quantitative PK/PD/efficacy relationships to support
project teams from early discovery through early clinical development.
In addition, the individual will be involved in (PK) and (ADME)
