[NMusers] Post-Doctoral Research Fellow/PhD position in Translational Pharmacology

2023-08-23 Thread D'Agate, Salvatore
 Join Our Team in Advancing Tuberculosis Research!  Position: PhD/Post-Doctoral Research Fellow in Translational Pharmacology Are you passionate about making a meaningful impact in the field of pharmaceutical sciences and eager to contribute to the fight against one of the world's most

Re: [NMusers] Observed (yaxis) vs Predicted (xaxis) Diagnostic Plot - Scientific basis.

2023-08-23 Thread Gobburu, Joga
Thank you, Wilbert. I was not aware of that publication – thank you for sharing! J From: Wilbert de Witte Date: Friday, August 18, 2023 at 2:08 AM To: Gobburu, Joga Cc: James G Wright , nmusers@globomaxnm.com Subject: Re: [NMusers] Observed (yaxis) vs Predicted (xaxis) Diagnostic Plot -

Re: [NMusers] Clarification on performance of mu referencing

2023-08-23 Thread Bill Denney
Hi Sébastien, My understanding is that keeping all thetas additive makes mu r referencing more efficient. The underlying mu reference math is then accurate for matrix linear formulations. My understanding is not perfect for this, so I'll defer to others if there is a different answer. Thanks,

[NMusers] Clarification on performance of mu referencing

2023-08-23 Thread Sébastien Bihorel
Hi Training material distributed during an ICON training contains the following verbatim statements about mu referencing " Code already defined as Typical Value (TV), actual value (as recommended by Beal) are easy to convert: – TVCL = THETA(1)*AGE**THETA(2) – MU_5 = LOG(TVCL) – CL =

Re: [NMusers] Observed (yaxis) vs Predicted (xaxis) Diagnostic Plot - Scientific basis.

2023-08-23 Thread Pyry Välitalo
Dear Martin and NMusers, With reference to Martin saying that “A greater problem with these plots is the commonly held expectation that for a "good model" a smooth or regression line should align with the line of unity. Though this seems intuitive it is a flawed assumption”, I would like to