RE: [NMusers] Absorption

Hello Adithya, You may want to check this article: Kerbusch T, Wahlby U, Milligan PA, Karlsson MO. Population pharmacokinetic modelling of darifenacin and its hydroxylated metabolite using pooled data, incorporating saturable first-pass metabolism, CYP2D6 genotype and

RE: [NMusers] IIV on %CV-Scale - Standard Error (SE)

Hello Jakob, I remember I developed code at one point to calculate a SE on a typical clearance which was a function of four covariates.. The general method is to use formula incorporating partial derivatives with respect to each parameter.

RE: [NMusers] 95% prediction interval and $OMEGA

Hello Kelong, Did you try to put TRUE=FINAL in the $simulation record. I suggest also to input you parameters using MSFI Bests, Samer -Original Message- From: [EMAIL PROTECTED] on behalf of Han, Kelong Sent: Thu 6/5/2008 21:49 To: nmusers@globomaxnm.com Subject: [NMusers] 95%

RE: [NMusers] warning no. 43 in NONMEM v.6.2

Hello Khaled, You can choose the calling procedure for $PK evaluations : * Refer to the documentation regarding : CALLFL file:///C:/nmvi/html/callfl.htm * Note that the default behavior can be different according to your model (if you have ALAG, ADDL etc..) * The warning is to tell you to

RE: [NMusers] Log Transformation in NONMEM

Hello Mohamed, You may find the following reference useful for your problem : Reference: PAGE 14 (2005) Abstr 773 [www.page-meeting.org/?abstract=773] Indirect-response model for the analysis of concentration-effect relationships in clinical trials where response variables are scores. V.

[NMusers] International One Week Summer School in PK PD Modeling (Montreal)

Dear NONMEM User's, Please find below information about a Summer School in PK/PD held in Montreal on August 18-22, 2008. Best Regards, Samer Summer School Trends in Mathematical Modeling in Medical and Pharmaceutical Sciences with Emphasis on PK/PD. Université de Montréal Pavillon

RE: [NMusers] PD of drugs in combination therapy

Dear Fatemeh, Some work regarding three drug combinations has been published regarding anesthetic combinations: Flexible interaction model for complex interactions of multiple anesthetics. Fidler M, Kern SE. Anesthesiology. 2006 Aug;105(2):286-96. Response surface model for anesthetic drug

RE: [NMusers] Coding a triple absorption model

Hello Mahesh, I recommend that your read the following paper: The use of a sum of inverse Gaussian functions to describe the absorption profile of drugs exhibiting complex absorption.Csajka C, Drover D, Verotta D. Pharm Res. 2005 Aug;22(8):1227-35. Epub 2005 Aug 3. It details how to constraint

RE: [NMusers] program terminated by NP4F

Dear Ethan, can you double check your data and see if you have any missing entries or blanks in some rows ? I recently submitted a similar issue to nmconsult to further investigate this error that happened with a dataset having an individual with some missing covariate values. Apparently the

RE: [NMusers] Steady state model

Hello Sherwin, All SS routines source code are located at the C:\nmvi\pr folder. Each Advan closed form model has specific routines (and equations for SS) that can be used with it. For linear models the magic factor for steady state computation will be: