Holford
Sent: Sunday, July 26, 2009 10:42 PM
To: nmusers
Subject: Re: AW: [NMusers] Simulations with/without residual error
Mats,
Thanks for extending the code fragment I proposed earlier to add some
extra useful features.
I don't know what was incorrect about the code I suggested
University
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-Original Message-
From: owner-nmus...@globomaxnm.com [mailto:owner-nmus...@globomaxnm.com] On
Behalf Of Nick Holford
Sent: Sunday, July 26, 2009 10:42 PM
To: nmusers
Subject: Re: AW: [NMusers] Simulations
Mats,
Thanks for extending the code fragment I proposed earlier to add some
extra useful features.
I don't know what was incorrect about the code I suggested but
resampling the uncertainty ETA values is a pragmatic way to avoid PREDPP
errors caused by randomly generated non-positive CL or V
Subject: Re: AW: [NMusers] Simulations with/without residual error
(Apologies for the delayed posting.. this apparently didn't make it to nmusers
on the initial attempt).
Dear Nick, Andreas, Andreas and nmusers,
Here are a couple of additional methods for including uncertainty in parameters
systems and checking
compliance with our Code of Conduct and policies.
-Original Message-
From: owner-nmus...@globomaxnm.com [mailto:owner-nmus...@globomaxnm.com
]On Behalf Of Gastonguay, Marc
Sent: 16 July 2009 18:59
To: nmusers
Subject: Re: AW: [NMusers] Simulations with/without residual
(Apologies for the delayed posting.. this apparently didn't make it to
nmusers on the initial attempt).
Dear Nick, Andreas, Andreas and nmusers,
Here are a couple of additional methods for including uncertainty in
parameters at the inter-trial (or inter-replicate) level, when
simulating
n.holf...@auckland.ac.nz
Sent by: owner-nmus...@globomaxnm.com
07/09/2009 11:51 AM
To
nmusers nmusers@globomaxnm.com
cc
Subject
Re: AW: [NMusers] Simulations with/without residual error
Andreas K,
It is not strictly true to say you cannot specify the parameter
uncertainties from a previous
cc
Subject
Re: AW: [NMusers] Simulations with/without residual error
Andreas K,
It is not strictly true to say you cannot specify the parameter
uncertainties from a previous run to be included in a simulation.
If you take the variance-covariance matrix
*To:* nmusers nmusers@globomaxnm.com
*Sent:* Friday, July 10, 2009 3:34:50 AM
*Subject:* Re: AW: [NMusers] Simulations with/without residual error
Andreas,
Thanks for your comments. I am sorry I did not explain everything that
NONMEM was doing in this simple example. It does not shave my face
Nick,
Thank you very much for your comments.
Indeed for VPC et al. i always simulate with residual error.
I understand that when one wants to simulate the 'true' value residual error
is not needed. But what if one wants to simulate 'real' values which will be
observed in a future study. For
Andreas,
I think you know the answer to your own question!
As I indicated before the use of residual error depends on the purpose
of the simulation. If you want to simulate future measurements then
residual error should be included
Nick
andreas lindauer wrote:
Nick,
Thank you very
-bonn.de
Sent by: owner-nmus...@globomaxnm.com
Date: 2009-07-09 09:42
Subject: AW: [NMusers] Simulations with/without residual error
Nick,
Thank you very much for your comments.
Indeed for VPC et al. i always simulate with residual error.
I understand that when one wants to simulate the 'true' value
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