Re: [NMusers] Time-Varying Bioavailability on Zero-Order Infusion

2018-03-15 Thread Alison Boeckmann
f R1 in $DES-- generalized to include all compartments.) > > Thanks, > > Bill > > -Original Message- > From: Leonid Gibiansky > Sent: Tuesday, March 13, 2018 9:34 PM > To: Sebastien Bihorel ; Bill Denney > > Cc: NMUsers > Subject: Re: [NMusers] Time

Re: [NMusers] Time-Varying Bioavailability on Zero-Order Infusion

2018-03-13 Thread Leonid Gibiansky
Message- From: Leonid Gibiansky Sent: Tuesday, March 13, 2018 9:34 PM To: Sebastien Bihorel ; Bill Denney Cc: NMUsers Subject: Re: [NMusers] Time-Varying Bioavailability on Zero-Order Infusion Hi Bill, I think the proposed original solution is the only one if you would like to imp

RE: [NMusers] Time-Varying Bioavailability on Zero-Order Infusion

2018-03-13 Thread Bill Denney
NONMEM should take care of the dosing in the background as usual. > > Sebastien > > -- > -- > *From: *"Bill Denney" > *To: *"NMUsers" > *Sent: *Tuesday, March 13, 2018 8:58:41 PM > *Subje

Re: [NMusers] Time-Varying Bioavailability on Zero-Order Infusion

2018-03-13 Thread Sebastien Bihorel
ent: Tuesday, March 13, 2018 9:17 PM To: Bill Denney < [ mailto:wden...@humanpredictions.com | wden...@humanpredictions.com ] > Cc: NMUsers < [ mailto:nmusers@globomaxnm.com | nmusers@globomaxnm.com ] > Subject: Re: [NMusers] Time-Varying Bioavailability on Zero-Order Infusion

Re: [NMusers] Time-Varying Bioavailability on Zero-Order Infusion

2018-03-13 Thread Leonid Gibiansky
*From: *"Bill Denney" *To: *"NMUsers" *Sent: *Tuesday, March 13, 2018 8:58:41 PM *Subject: *[NMusers] Time-Varying Bioavailability on Zero-Order Infusion Hi NONMEMers, Is there a good way to assign a time-varying bioavailabilty on a zero-order rate of infusion in NONMEM?  The

Re: [NMusers] Time-Varying Bioavailability on Zero-Order Infusion

2018-03-13 Thread Sebastien Bihorel
gt; Sent: Tuesday, March 13, 2018 9:17 PM To: Bill Denney < [ mailto:wden...@humanpredictions.com | wden...@humanpredictions.com ] > Cc: NMUsers < [ mailto:nmusers@globomaxnm.com | nmusers@globomaxnm.com ] > Subject: Re: [NMusers] Time-Varying Bioavailability on Zero-Order Infusi

RE: [NMusers] Time-Varying Bioavailability on Zero-Order Infusion

2018-03-13 Thread Bill Denney
solution does that, but I’d like to learn a simpler way than what I suggested. Thanks, Bill *From:* Sebastien Bihorel *Sent:* Tuesday, March 13, 2018 9:17 PM *To:* Bill Denney *Cc:* NMUsers *Subject:* Re: [NMusers] Time-Varying Bioavailability on Zero-Order Infusion Hi, I would suggest

Re: [NMusers] Time-Varying Bioavailability on Zero-Order Infusion

2018-03-13 Thread Sebastien Bihorel
Hi, You may also have to define $BIND if your F1 expression is dependent on dataset variables. From: "Sebastien Bihorel" To: "Bill Denney" Cc: "NMUsers" Sent: Tuesday, March 13, 2018 9:16:56 PM Subject: Re: [NMusers] Time-Varying Bioavailability on Zero-

Re: [NMusers] Time-Varying Bioavailability on Zero-Order Infusion

2018-03-13 Thread Sebastien Bihorel
... ; assuming the IV infusion are made in compartment 1 F1 = R1 = F1*IVRATE Voila, NONMEM should take care of the dosing in the background as usual. Sebastien From: "Bill Denney" To: "NMUsers" Sent: Tuesday, March 13, 2018 8:58:41 PM Subject: [NMusers] Time-Varying Bioavaila

[NMusers] Time-Varying Bioavailability on Zero-Order Infusion

2018-03-13 Thread Bill Denney
Hi NONMEMers, Is there a good way to assign a time-varying bioavailabilty on a zero-order rate of infusion in NONMEM? The best I’ve been able to come up with is something like the below. It seems like something that should be easier than what I’m doing below (I adjusted it from the real exampl