f R1 in $DES-- generalized to include all compartments.)
>
> Thanks,
>
> Bill
>
> -Original Message-
> From: Leonid Gibiansky
> Sent: Tuesday, March 13, 2018 9:34 PM
> To: Sebastien Bihorel ; Bill Denney
>
> Cc: NMUsers
> Subject: Re: [NMusers] Time
Message-
From: Leonid Gibiansky
Sent: Tuesday, March 13, 2018 9:34 PM
To: Sebastien Bihorel ; Bill Denney
Cc: NMUsers
Subject: Re: [NMusers] Time-Varying Bioavailability on Zero-Order Infusion
Hi Bill,
I think the proposed original solution is the only one if you would like to
imp
NONMEM should take care of the dosing in the background as usual.
>
> Sebastien
>
> --
> --
> *From: *"Bill Denney"
> *To: *"NMUsers"
> *Sent: *Tuesday, March 13, 2018 8:58:41 PM
> *Subje
ent: Tuesday, March 13, 2018 9:17 PM
To: Bill Denney < [ mailto:wden...@humanpredictions.com |
wden...@humanpredictions.com ] >
Cc: NMUsers < [ mailto:nmusers@globomaxnm.com | nmusers@globomaxnm.com ] >
Subject: Re: [NMusers] Time-Varying Bioavailability on Zero-Order Infusion
*From: *"Bill Denney"
*To: *"NMUsers"
*Sent: *Tuesday, March 13, 2018 8:58:41 PM
*Subject: *[NMusers] Time-Varying Bioavailability on Zero-Order Infusion
Hi NONMEMers,
Is there a good way to assign a time-varying bioavailabilty on a
zero-order rate of infusion in NONMEM? The
gt;
Sent: Tuesday, March 13, 2018 9:17 PM
To: Bill Denney < [ mailto:wden...@humanpredictions.com |
wden...@humanpredictions.com ] >
Cc: NMUsers < [ mailto:nmusers@globomaxnm.com | nmusers@globomaxnm.com ] >
Subject: Re: [NMusers] Time-Varying Bioavailability on Zero-Order Infusi
solution does that, but I’d like to learn a simpler
way than what I suggested.
Thanks,
Bill
*From:* Sebastien Bihorel
*Sent:* Tuesday, March 13, 2018 9:17 PM
*To:* Bill Denney
*Cc:* NMUsers
*Subject:* Re: [NMusers] Time-Varying Bioavailability on Zero-Order Infusion
Hi,
I would suggest
Hi,
You may also have to define $BIND if your F1 expression is dependent on dataset
variables.
From: "Sebastien Bihorel"
To: "Bill Denney"
Cc: "NMUsers"
Sent: Tuesday, March 13, 2018 9:16:56 PM
Subject: Re: [NMusers] Time-Varying Bioavailability on Zero-
...
; assuming the IV infusion are made in compartment 1
F1 =
R1 = F1*IVRATE
Voila, NONMEM should take care of the dosing in the background as usual.
Sebastien
From: "Bill Denney"
To: "NMUsers"
Sent: Tuesday, March 13, 2018 8:58:41 PM
Subject: [NMusers] Time-Varying Bioavaila
Hi NONMEMers,
Is there a good way to assign a time-varying bioavailabilty on a zero-order
rate of infusion in NONMEM? The best I’ve been able to come up with is
something like the below. It seems like something that should be easier
than what I’m doing below (I adjusted it from the real exampl
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