*À :* Saeheum Song
*Cc :* Le Louedec Felicien ;
nmusers@globomaxnm.com; Leonid Gibiansky
*Objet :* Re: [NMusers] Time-varying bioavailability and reproducibility
in NONMEM analysis
Can you please share the ds_sim_told.csv file (or at least 2 complete
individuals from that file)? It
;
>> ALAG = TVALAG ;
>> Q= TVQ ;
>> VP = TVVP ;
>> LAMBDA = TVLAMBDA / 24 ;
>> MAXDECR = TVMAXDECR ;
>>
>> TVF = 1 - MAXDECR + MAXDECR * exp(-LAMBDA*TOLD) ;
>> F1 = TVF ;
>>
>> K20 = CL / VC ;
>> K23 = Q /
RIPHERAL ;
> dxdt_PERIPHERAL = K23 * CENTRAL - K32 * PERIPHERAL;
>
> $CAPTURE @annotated
> DV : Concentration central (mcg/L)
> F_DEPOT : F
>
> end of MRGSOLVE CODE
>
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> -Message d'origine-
> De : owner-nmus...@globo
ner-nmus...@globomaxnm.com] De la
part de Leonid Gibiansky
Envoyé : mardi 11 février 2020 15:19
À : nmusers@globomaxnm.com
Objet : Re: [NMusers] Time-varying bioavailability and reproducibility in
NONMEM analysis
could you show equations? Bioavailability is treated differently in Nonmem and
R, so code should re
:19
À : nmusers@globomaxnm.com
Objet : Re: [NMusers] Time-varying bioavailability and reproducibility in
NONMEM analysis
could you show equations? Bioavailability is treated differently in Nonmem and
R, so code should reflect it.
Thanks
Leonid
On 2/11/2020 3:52 AM, Le Louedec Felicien wrote:
&
could you show equations? Bioavailability is treated differently in
Nonmem and R, so code should reflect it.
Thanks
Leonid
On 2/11/2020 3:52 AM, Le Louedec Felicien wrote:
Dear NONMEM users,
I’m struggling for a couple of weeks against contradictory results
between NONMEM and R analysis of t
