[spctools-discuss] Re: Reg:TPP combatibility with Shimadzu MALDI-TOF-TOF data

2009-02-18 Thread mnotes
Hi David: Thank you, David, for interesting conversation. The world you just described does not exits, fortunately I would say, and it is probably a time to think about real world which is outside of all-round but practically useless mathematical models. Sergey On Feb 18, 12:55 am, David

[spctools-discuss] Re: Reg:TPP combatibility with Shimadzu MALDI-TOF-TOF data

2009-02-17 Thread mnotes
For two independent experimental data probability of particular scan to match particular peptide should not depend on data in second independent experiment that is why they are independent experiments. With PeptideProphet when you combine two data sets in interact.xml and process them together

[spctools-discuss] Re: Reg:TPP combatibility with Shimadzu MALDI-TOF-TOF data

2009-02-17 Thread David Shteynberg
I don't agree that any hidden links are introduced, rather some incorrect assumptions are exposed. When datasets are analyzed together this is very explicit. When you are expecting that these datasets should be independent but you are finding that you get different results when you are