The dictum in antibiotic prescription is no change in loading dose of 
antibiotic with any co morbidity

On 17-Sep-2013, at 22:57, "Harkey,Jessica" <[email protected]> wrote:

> Hello there. I have been having some discussion with our pharmacists on 
> whether or not patients who present to the ED in severe sepsis or septic 
> shock should receive a full dose of an aminoglycoside (when indicated) within 
> the first hour regardless of Cr clearance? The practice of our ED physicians 
> thus far has been to order a full dose, and now we are getting some feedback 
> from pharmacy to reduce the dose per renal function, which seems appropriate 
> with consecutive doses along with monitoring drug levels. I am concerned 
> about delaying administration.  For initial empric therapy what are the rest 
> of you doing in such cases? Any literature available for me to share with the 
> pharmacy?
> Thank you!
>  
> Jessica Harkey, RN, BSN, CCRN
> Sepsis Program Coordinator
> San Joaquin Community Hospital
> 661-869-6874
> [email protected]
> <image001.png>
>  
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