On Fri, Apr 22, 2011 at 06:16:59PM +0530, ss wrote:

> I think the old habit of doing "upvaasa" - fasting once a week - and on 

Alternate day fasting is about optimal, if you can pull it
off. Gives you all the benefits of calorie restriction, without
the side effects.

> certain other days might be a good idea. Getting up and walking arond a lot 
> more would help.

Apparently no amount of movement can completely compensate sedentary time.
I try to walk more during work, including alternating working
at a standing desk and sitting down (I also have a Swopper
chair clone, though I rarely use it).
 
> But then again - no guranatees. Medical science just does not know why the 
> entie world is getting obese. Everyone is guessing. The only thing that sets 

Higher calorie intake than you burn. (In my case, also alcohol
metabolism shift to acetate, and lower quality of sleep due
to same culprit). There are shady things you can do with
supplementation to adjust hormone level and jack up mitochondria
metabolism but they're likely to do more harm than good.

Here's a list by a friend of mine which might or might not 
make sense, caveat lector:

Essential daily nutrition
  1. 2-3 litres (1 gallon) of water (for dehydration-, inflammation-
and disease- prevention, proper detoxification and metabolic/enzymatic
activity and appetite control)
  2. 1-2 litres green tea (ideally, low-caf brand or -preparation;
for its significant cancer-/obesity-/heart-disease prevention
effects). Otherwise: at least 3-4 servings of polyphenol rich fruit
(berries or anything else with strong colours)
  3. Basic Multivitamin/-mineral , dosed according to Optimal
Nutritional Allowance, above RDA guidelines. Including at least 5.000
IE Vitamin D (safe for everyone; lowers all-cause-mortality, and
especially heart disease and cancer risks)
  4. EPA/DHA fatty-acids, i.e. 2-3 Grams of (mercury-free) Fish oil
(anti-obesity, immune-modulating, brain volume, cardioprotective
anti-inflammation, joint protection, etc.)
  5. Mitochondrial support: 500 mg Acetyl-L-Carnitine and 125 mg
R-Alpha-Lipoic Acid, ideally with 200 mg Coenzyme Q10 (guards against
age-associated frailty, cardiovascular problems, diabetes, obesity,
many cancers. many more)

Essential exercise
  1. 30 minutes running or 1 hour walking (at least 400 min. walking
or 200 min. running a week)
  2. 15 minutes stretching and calisthenics (e.g. push-ups) (at least
100 min. a week; prevention of degenerative joint, muscle, back, etc.
problems)
  3. mind exercise and avoiding significantly more than 8 hours sleep
a day on average

Essential prevention and -don'ts
  1. Don't engage in physically risky or foolish behavior (avoid
dangerous situations, e.g. in crowds, extreme sports, highway traffic,
toxic substances and environments, all illegal drugs, be prepared for
efficient self-defense in possible assaults)
  2. Avoid moderate to high amounts of sugar
  3. Avoid low-fiber, 'empty' carbohydrates (in pasta, bread and
other non-whole-grain products, etc.; this already has a moderate, but
significant caloric restriction effect)
  4. Avoid alcohol, ideally at all, but especially all
high-percentage, and of course don't smoke.
  5. Avoid products very high in animal fat (fatty meat and high-fat
dairy) and red meat (pro-inflammatory)
  6. Avoid regular high amounts of caffeine (high blood pressure ->
endothelial damage -> atherosclerosis to name just one problem)
  7. Dental hygiene incl. flossing (tooth decay causes
atherosclerosis and inflammation)
  8. Regular physician checkups as officially recommended (including
at least: bi-annual dentist, blood sugar and CBC, eye, cardio,
uro-/gynecological, coloscopy, cancer screening)
  9. Check both resting and active blood pressure and pulse at least annually
 10. Most important blood values: kidney and liver panel, hs-CRP,
Vitamin D, HDL, LDL, hormones: DHEA, pregnenolone, testosterone,
thyroid (fT3/fT4)

Advanced nutrition (if you have the time and money):
  1. Regular detoxification assistance and toxicity prevention,
including high-dose N-acetyl-cysteine (NAC; 600-1200 mg/day), fiber,
silymarin (liver protection), alfalfa, chlorophyllin, digestive
enzymes, algae, chelating agents (e.g. MSM), etc.
  2. To assure optimum methylation and keep homocysteine low,
consider: high-dose folate and B vitamins (esp. B6 and B12 as
methylcobalamin), trimethylglycine, s-adenosyl-methionine
  3. To prevent chronic inflammation, especially modulating
nuclear-factor-kappa-beta and IL-6, consider: low-dose aspirin,
high-dose EPA/DHA fatty acids, gamma-linoleic acid, curcumin,
whole-spectrum tocopherols/tocotrienols and others
  4. Caloric-restriction mimetics, including (ordered from safe to
purely experimental!): resveratrol, R+-alpha-lipoic-acid, metformin
and other biguanides, doing intermittent fasting, 2-deoxy-D-glucose,
NTBHA, PBN, exanadin.
  5. Protecting against mitochondrial energy depletion and
mtDNA-damage: carnitin/lipoic acid combinations (most effective:
acetyl-l-carnitine arginate HCL with R-lipoic-acid), high-dose CoQ10
  6. Protect against glycation by L-carnosine, and reverse
glycation-end-products, currently mostly  possible by ALT-711 aka
dimethyl-3-phenacylthiazolium chloride
  7. Nootropics that protect brain cells (vitamin B12 as
methylcobalamin, oxygen metabolism improvers such as vinpocetine,
etc.), improve their function and help cleaning out cellular 'garbage'
in neurons and the rest of the body, such as amyloid/lipofuscin
(low-dose deprenyl, hydergine, racetams, centrophenoxine, etc.)
  8. DHEA, Thyroxin and Melatonin replacement to healthy blood levels
of a 25-year old
  9. SuperOxide Dismutase (SOD) boosters (e.g. SODzyme™, GliSODin®,
glutathione, NAC or just whey protein which increases glutathione as
well)
 10. To partially reverse or prevent progression of atherosclerotic
plaque: consider natural cholesterol-lowering drugs (policosanol,
high-dose niacin, beta-sitosterin, green tea extract, sytrinol,
curcumin, bromelain, etc.), ideally in combination with statin drugs
(under high-dose CoQ10 supplementation and only under physician
supervision with regular blood testing)

> apart Lustig from the other guessers is that he, in the tue tradition of 
> modern science, has gone one step closer to proving that refined sugar is a 
> problem. That leaves a whole lot of other unknowns that have no answers 
> currently.

-- 
Eugen* Leitl <a href="http://leitl.org";>leitl</a> http://leitl.org
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