Please note that they are talking about "Silver Proteins, Colloidal Silver
Proteins", which relate to the original post concerning the lastest form of
"snake oil", not what we make here.
Best Regards,
Arnold Beland
www.atlasnova.com
----- Original Message -----
From: "Pat" <pattycake29...@yahoo.com>
To: "silver list" <silver-list@eskimo.com>
Sent: Sunday, May 18, 2008 4:13 PM
Subject: CS>Molecula Silver .. comments please
The link you sent said not found. This is what I found at Sloan-Kettering
( http://www.mskcc.org/mskcc/html/69189.cfm ) , not exactly what I
wanted to hear.
Pat
Common Name
Silver Proteins, Colloidal Silver Proteins, Colloidal Silver Water
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Clinical Summary
Colloidal
silver consists of silver particles suspended in a liquid. It is often
produced by home-made generators. The use of silver medicinals to treat
disorders such as epilepsy, gonorrhea, and colds was not uncommon until
the mid-20th century. However, silver was replaced by safer therapies
in the recent decades. While silver compounds are still used in
external preparations as antiseptics, there has been a growing interest
in using the collodial form of silver orally as an alternative
medicine. Although no human clinical data support the use of oral
colloidal silver, it is being promoted as a cure for AIDS, cancer, and
diabetes. Silver is not an essential mineral and does not serve any
physiological function in the body. It actually denatures proteins by
binding to their reactive groups. It can inactivate some enzymes by
forming hemisilver sulfides with sulfhydryl groups of the enzymes (1).
Silver when taken orally can interact with and reduce the effectiveness
of tetracycline, quinolone, and penicillamine. Long term use can cause
silver deposition in the skin and mucous membranes leading to an
irreversible condition called argyria, characterized by bluish-gray to
gray-black pigmentation (2) (3). Other adverse effects include seizures
(6) and kidney damage. Pregnant women should not consume colloidal silver
as it can cause developmental abnormalities in the fetus (1).
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Purported uses
* AIDS
* Cancer treatment
* Diabetes
* Immunostimulation
* Infections
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Constituents
* Silver particles suspended in liquid.
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Mechanism of Action
Silver
is unstable in suspension form and can bind to proteins. Silver
compounds form hemisilver sulfides with sulfhydryl groups that leads to
inactivation of enzymes. Silver also has the ability to bind amino,
carboxyl, phosphate and imidazole groups (1).
Studies have shown that silver accumulates in rat liver and binds with
various tissues and basal membranes. It also affects the activities of
lactate dehydrogenase and glutathione peroxidase and the peroxidation
of membrane lipids (4).
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Pharmacokinetics
Approximately
10% of silver salts may be absorbed following ingestion, with increased
absorption from ruptured mucus membranes and skin wounds. The half-life
varies from several days to months but silver deposited in the skin has
a much longer half-life. It is excreted into the bile and eliminated in
the feces (1).
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Warnings
The
Food and Drug Administration (FDA) declared that all over-the-counter
drugs containing colloidal silver are not recognized as safe and
effective and are misbranded (7).
The FDA has also recently issued letters to website operators of
colloidal silver warning them that it is illegal to promote such
products online (8).
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Contraindications
Pregnant women should not use colloidal silver as it can cause
developmental abnormalities in the fetus (1).
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Adverse Reactions
Reported (Oral): Accumulation
of silver in the body causes argyria, a bluish-gray discoloration of
the skin, which is untreatable. Other effects include seizures and
kidney damage.
Reported (Topical): Topical use of silver nitrate for burns may cause
methemoglobinemia.
Exposure to high concentrations of silver, such as in an industrial
setting, leads to systemic toxicity (1) (5).
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Herb-Drug Interactions
* Antibiotics: Colloidal silver can reduce the bioavailability of
antibiotics such as tetracycline and quinolone.
* Penicillamine: Colloidal silver can reduce the effectiveness of drugs
such as penicillamine by binding to the drug.
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Literature Summary and Critique
No
human studies have been conducted to test the medicinal effects of
colloidal silver. There are a few case reports on its toxicity.
McKenna JK, et al Argyria associated with colloidal silver
supplementation. Int J Dermatol 2003; 42(7):549.
A
65-year old male developed skin discoloration but had no other
symptoms. He had consumed colloidal silver supplements for two years
for treatment of diabetes. The discoloration was limited to fingernails
but could not be treated by depigmenting creams or chelation. The
patient was advised to use sunscreens to prevent further pigmentary
changes.
Gulbranson SH, Hud JA, Hansen RC. Argyria following the use of dietary
supplements containing colloidal silver protein. Cutis 2000;
66(5):373-374.
A
56-year old man developed bluish discoloration of fingernails (argyria)
following consumption of colloidal silver for cold and allergy for 3
years. There was no improvement in the appearance of fingernails 3
months after the patient stopped consuming colloidal silver. He was
advised to avoid sun exposure to prevent further discoloration.
Mirsattari SM, et al. Myoclonic status epilepticus following repeated oral
ingestion of colloidal silver. Neurology 2004;62:1408-10.
A
71-year old man developed myoclonic status epilepticus and coma
following daily ingestion of one ounce of colloidal silver and various
herbal remedies for stage B adenocarcinoma of the prostate for a period
of 4 months. High levels of silver were found in the plasma,
erythrocytes, and cerebrospinal fluid. He remained in a vegetative
state and died 5.5 months later despite extensive treatment.
Researchers concluded that the neurotoxicity and the resulting death
were due to ingestion of colloidal silver.
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