Mr Bradley
Your many researches and sharing of information is greatly appreciated
by many.
Since you make an appearance here on this forum, I will take the
opportunity to ask your opinion on liposomes, another of your wonderful
experiments.
We were unable to find any literature that suggested liposomes make it
intact beyond the lining of the small intestine. Further, if they are
injected directly into the blood stream, there is a massive immune
response clearing them quickly.
There seems to be an idea widely held that the liposomes are absorbed
intact, and merge with cells directly, and this gives 2 to 5, or greater
bio-availability. After scanning pub med articles, this idea seems to
be urban myth. Yet, clinicians and laypersons seem to like the results
of liposome encapsultated vitamin C, and there is a trend toward
microencapsulation of other substances. The best idea we can formulate
so far is that the lecithin liposomes protect the enclosed ingredient
somewhat from the stomach, are broken down in the small intestine,
digested down to molecular levels and reformulated into chylomicrons, a
standard biological process for fats. The increase in bioavailability
remains a mystery. The body uses the so called sodium depended pump
uptake system for vit C. It seems possible that the ascorbic acid might
"ride" on fat uptake pathways, or simply that there is greater gut
retention time, and this gives a moderate increase in plasma ascorbate
levels. In any case, the small increase of plasma ascorbic acid, and
only at the highest level of intake, as suggested by the literature
seems hardly enough to account for the rave reviews of people taking,
and making, liposomal preparations.
Your thoughts on this interesting subject are appreciated.
Thank you
Marcy
On 3/8/2013 2:52 PM, Brooks Bradley wrote:
Dear Roger,
If you are considering "self-experimentation" and/or
protocols developed for evaluations involving cats or dogs, etc......I
suggest you consider DIY approach, using readily-available "bulk
quantity" substances. e.g. We used bulk Carnosine
powder (about $25.00 for 50 grams) [source was Beyond-a-Century.com ]. One
might use Carnitine, instead for Carnosine, but there is better
evidence for the
Carnosine derivative over the Carnitine ......in such applications as
ancillary
elements in addressing cataract presentations. One of the most simple, and
effective combinations which we employed is one wherein a solution of
1% [or even 2% in some cases], by volume, of Saturated-solution of
Carnosine is
mixed with 5% undiluted DMSO, by volume.....and the remaining 97%/98%,
by volume, is distilled water. The parent stock (the mixed solution)
will last quite some time (some months), if not subjected to freezing
and/or heating cycles.
Applications of these eye-drops one to 3 times daily, yielded
excellent responses for the vast majority of experimental cases
(animal pets and humans alike).....of better than
80%, from among our experimental subjects.
If you are considering the use of the Carnitine fraction,
instead of the Carnosine......I suggest you read up on the EXACT
differences via a web search.
Actually, we accomplished EVEN BETTER RESULTS from a solution
containing a couple of other non-toxic amendments---but I will not
recommend
their inclusion--------as our data involving their inclusion is far
too limited for a general extrapolation.
Incidentally, our research achieved SPLENDID EFFECTS from the
utilization of astaxanthin (and this was accomplished some YEARS
before the
current episode of general endorsements by the mainstream alternative health
community....for using astaxanthin). Additionally, oral incorporation
of astaxanthin
has demonstrated (especially recently) to be UNUSUALLY effective in
addressing macular degeneration. Achieving corrective influence in
some cases,
and prevention of advancement........in approximately 75% of all volunteers.
To our present knowledge, NO OTHER extant protocol (chemical or mechanical)
has displayed ANY measurable influence on macular degeneration. Our
results were the result of anecdotal (as against double-blind)
protocols, so are susceptible to denigration from the extremist
segment of the allopathic community.
I suggest you prosecute a general Web-search on astaxanthin
as a supportive protocol for macular degeneration....you should
receive much
useful information/data.
Sincerely, Brooks Bradley.
.....
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