Ivan Anderson wrote:

The interaction of colloidal metals with erythrocytes.

> J Inorg Biochem, 56: 4, 1994 Dec, 283-90
>
> Abstract
> The interactions of citrate reduced colloids (Ag, Au, and Bi) with
> intact erythrocytes and erythrocyte lysate have been studied by 1H
> spin echo NMR. Silver colloid is observed to induce cellular depletion
> of cytosolic glutathione and bismuth colloid induces cytosolic
> glutathione oxidation in the intact cell. In comparison, there is no
> detectable effect with gold colloid. With red cell lysate the three
> colloids all remove glutathione from the spectrum. The metal salts
> AgNO3 and NaAuCl4 both oxidize intracellular glutathione to
> diglutathione whereas BiO(NO3) has no effect. Thus colloidal
> preparations have a different reactivity to their parent metal salts.
> The differences observed between the three types of colloids (silver,
> gold, and bismuth) are unique to the colloids studied. None of the
> colloids studied were biologically inert in the erythrocyte model
> used.

I wonder if one should take selenium with CS then to replace the cytosolic
glutathione which is apparently an antioxidant.

Marshall


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