Furst and Schlauder (1977) evaluated silver and gold for carcinogenicity
in a study designed to avoid solid-state carcinogenesis. Metal powder was
suspended in trioctanoin and injected monthly, i.m., into 50 male and
female
Fischer 344 rats per group. The dose was 5 mg each for 5 treatments and
10 mg
each for 5 more treatments for a total dose of 75 mg silver. The treatment
regimen included a vehicle control (a reportedly inert material), and
cadmium
as a positive control. Injection site sarcomas were found only in vehicle
control (1/50), gold (1/50) and cadmium (30/50); no tumors (0/50)
appeared at
the site of injection in the silver-treated animals. A complete necropsy
was
performed on all animals. The authors mentioned the existence of
spontaneous
tumors in Fischer 344 rats, but reported only injection site tumors. They
concluded that finely divided silver powder injected i.m. does not induce
cancer.
>
>http://www.epa.gov/ngispgm3/iris/subst/0099.htm
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