Seems like osmotic pressure may have distorted the  eyeball.

I wonder if they were monitoring intraocular pressures? 

JOH

-----Original Message-----
From: Garnet [mailto:[email protected]] 
Sent: Monday, May 03, 2004 9:54 AM
To: [email protected]
Subject: Re: CS>RE: CS>DMSO - other side?


From: DMSO Nature's Miracle by Walker

5 mg/kg for 90 days caused refractive index changes but not lens opacity,
the animals became slightly nearsighted at a dose 50-100 times that the
usual human therapeutic dose. The problem diminished as the dose was
reduced. The tests on primates showed none of these effects and seems
limited to rabbits, dogs and pigs at high doses.  DMSO Nature's Miracle by
Walker pp79

"No changes in refraction or translucense of the lens or any other
abnormalities were noted in any animal [primates] before, druing or 18 weeks
after any drug administration." Dr JC de la Torre, Department of
Neurosurgery (r-35), Univeristy of Miami School of Medicine, PI Box 076960
Miami, FA 33101. Reprint available. Journal of Toxicology and Environmental
Health Vol 7, March 1981

It seems that in extremely high doses for prolonger periods dogs, pigs and
rabbits may show some changes. But these dosages are not therapeutic and no
such effects were seen in primates or humans. Even the changes in rabbits,
known to be very sensitive and therefore the model for such experiments,
were only found at very high doses for many months.

Garnet

On Mon, 2004-05-03 at 07:24, Tony Moody wrote:
> Hi James,
> Nah, the massive doses of DMSO (10 g/kg of bunny over 3 months
> made them slightly shortsighted but did NOT affect opacity. Also the 
> bunnies had been used for a previous experiment involving laxative 
> (from memory) which might have "distorted" the results. I'll find that 
> and scan it.
> 
> But you are probably right about the rest.
> Tony
> 
> On 2 May 2004 at 21:31, James Holmes wrote:
> 
> > There was one study where massive amounts of DMSO were given to 
> > rabbits. They developed cloudy areas in the lens.
> > 
> > No one has been able to make it happen again.
> > 
> > Most think it is a scam to discredit a cheap and effective 
> > substance.
> > 
> > JOH
> > 
> > -----Original Message-----
> > From: sol [mailto:[email protected]]
> > Sent: Saturday, May 01, 2004 5:26 PM
> > To: [email protected]
> > Subject: Re: CS>DMSO - other side?
> > 
> > 
> > Garnet,
> >   Can you point me to any details about the ocular effects in rabbits?
> >   I
> > use a little DMSO in my nebulizing and ear drop mix for my bunny, and
> > sure don't want to hurt his eyes. Were those tests done actually
> > putting DMSO into the eyes? My little guy is deaf, so he certainly
> > doesn't need his vision impaired. paula
> > 
> > Garnet wrote:
> > 
> > >(DMSO) It was banned for human use when it was found in the 60's to 
> > >have ocular effects in rabbits, the standard lab model for eyes. 
> > >Well  it does not do this to primates or humans.
> > >
> 
> 
> 
> 
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