Here is an excerpt from Vitamin Research News bulletin of Sept.
2001.<www.VRP.com>re Dupuytrens contracture and Peyronies.I followed this
protocol using PABA successfully to stop and reverse Peyronies.I used
approx.3 to 4 grams per day.
PABA as an Anti-Crosslinking Agent
The crosslinkage theory of aging was
proposed by Professor Johan Bjork-sten
in 1974. Bjorksten believed that the aging
process was due to crosslinks (undesir-
able bonds induced by excess free radi-
cals) which formed between molecules).
Bjorksten theorized that these crosslinks
progressively impaired the function of the
body, the end result of which was aging.
PABA appears to slow and in some cases
even reverse crosslinking in the protein
structures of connective tissues such as collagen.
Collagen crosslinking-- is the primary process in a
number of fibrotic diseases, including: .
Peyronie's disease (formation of fibrotic
plaques of the penis~ usually in men over
50, resulting in painful, "crooked" erec-
tions, rendering intercourse difficult or
impossible); Dupuytren 's contracture -
(wherein the flexor tendons of the fingers -
of the hands become fibrotic and contract,
rendering the fingers useless); and sclero-
derma (a rare condition characterized by
heavily crosslinked skin and tissues, with
d(1964) found PABA to have a marked
therapeutic effect in these conditions, in' .
doses of 12 grams per day.21 Zarafonetis
also used PABA to treat dermatitis her-
petiformis (200 mg, 4-5 times daily), and
vitiligo (a depigmenting disease). By
slowing crosslinking, PABA may pro-
mote greater body flexibility in normally
aging individuals.
Potential Side Effects and Cautions
High-dose PABA is generally well-
tolerated, its most significant adverse side
effects being diarrhea and nausea, which
resolved with cessation of use, or lowering
of tlie dose. As PABA is water soluble, it is
rapidly excreted in the urine, and must
therefore be administered in divided doses
throughout the day. High-dose PABA
should be discontinued when taking sulfa
antibiotics (like Bactrim or Septra).
I hope this helps,
Harold
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