Hi All,

 I think this abstract gives some sens of the effects of radiation in
the presence of silver.  It appears to me that those who advisde
against are doing this because they have no knowledge from which to
formulate a true response.


Int J Radiat Biol. 1992 Mar;61(3):369-79.

Increased radiation tolerance of mouse tongue epithelium after local
conditioning.

Dorr W, Kummermehr J.

GSF-Institut fur Strahlenbiologie, W-8042 Neuherberg, Germany.

The effect of local stimulation on mitotic activity and radiation
tolerance was studied in mouse tongue mucosa. Silver nitrate solution
(0.5-20%) was used for local conditioning. The most effective protocol
comprised three daily treatments (days 0-2), yielding a delayed
increase in 24 h mitotic counts by about 30% on days 5-7. The
stimulating effect was independent of silver nitrate concentration.
Sham treatment with saline or anaesthesia alone clearly depressed
mitotic activity on days 2-4 without any subsequent overshoot.
Radiation treatment was initiated on day 5 after three daily
treatments with 3% silver nitrate solution. A top-up technique was
employed, consisting of fractionated irradiation (300 kV X-rays) of
the whole snout, followed by graded local test doses (25 kV X-rays) to
induce denudation in a confined area of the inferior tongue surface.
Silver nitrate conditioning did not alter the radiosensitivity of the
epithelium to single local doses, but shortened the latency to
denudation from 11 to 8 days. In contrast, a clear increase in
tolerance to fractionated irradiation, delivering 5 x 2.5, 5 x 3.5, 5
x 4.5 Gy or 3 x 5.2 Gy in 7 days, was observed, equivalent to about
four, two, one and two extra dose fractions. This approach may be a
suitable way to increase radiation tolerance of oral mucosa in
clinical radiotherapy.

PMID: 1347070

--
Regards,
Catherine

"Some men have thousands of reasons why they cannot do what they want
to, when all they need is one reason why they can." -- Mary Frances
Berry


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