Interesting, so silver, even in minute amounts, reduces the mitotic
activity by 30%.  So I would expect silver to reduce the likelyhood of the
formation of cancer causing cells from radiation to also be reduced by
30%.

Marshall

Catherine Creel wrote:

>   Hi All,
>
>   I think this abstract gives some sens of the effects of radiation in
> the presence of silver.  It appears to me that those who advisde
> against are doing this because they have no knowledge from which to
> formulate a true response.
>
> Int J Radiat Biol. 1992 Mar;61(3):369-79.
>
> Increased radiation tolerance of mouse tongue epithelium after local
> conditioning.
>
> Dorr W, Kummermehr J.
>
> GSF-Institut fur Strahlenbiologie, W-8042 Neuherberg, Germany.
>
> The effect of local stimulation on mitotic activity and radiation
> tolerance was studied in mouse tongue mucosa. Silver nitrate solution
> (0.5-20%) was used for local conditioning. The most effective protocol
> comprised three daily treatments (days 0-2), yielding a delayed
> increase in 24 h mitotic counts by about 30% on days 5-7. The
> stimulating effect was independent of silver nitrate concentration.
> Sham treatment with saline or anaesthesia alone clearly depressed
> mitotic activity on days 2-4 without any subsequent overshoot.
> Radiation treatment was initiated on day 5 after three daily
> treatments with 3% silver nitrate solution. A top-up technique was
> employed, consisting of fractionated irradiation (300 kV X-rays) of
> the whole snout, followed by graded local test doses (25 kV X-rays) to
> induce denudation in a confined area of the inferior tongue surface.
> Silver nitrate conditioning did not alter the radiosensitivity of the
> epithelium to single local doses, but shortened the latency to
> denudation from 11 to 8 days. In contrast, a clear increase in
> tolerance to fractionated irradiation, delivering 5 x 2.5, 5 x 3.5, 5
> x 4.5 Gy or 3 x 5.2 Gy in 7 days, was observed, equivalent to about
> four, two, one and two extra dose fractions. This approach may be a
> suitable way to increase radiation tolerance of oral mucosa in
> clinical radiotherapy.
>
> PMID: 1347070
>
> --
> Regards,
> Catherine
>
> "Some men have thousands of reasons why they cannot do what they want
> to, when all they need is one reason why they can." -- Mary Frances
> Berry
>
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