Simon,
2. Is it possible to mix 'full' machines with LTSP machines?
An alternative is to setup some LTSP machines to use 'local apps'. In this configuration rather than the applications running on the server with the X display being sent to the desktop, the servers file system(s) are attached to the desktop using NFS and the applications run on the CPU of the desktop. This means that the desktops hardware, such as USB ports, are local to the GUI applications. But the software resides on the filesystem of the server so you still get single point for software update and user file storage, but you off-load the CPU resource to the desktop PC.
HTH
P.
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