dear list,

when running following command (tpp 4.3.1)

/usr/local/apps/tpp/bin/xinteract
-N/IMSB/results/workflow/45/Xinteract_/Xinteract.pep.xml -dDECOY_ -OAlIwp
/IMSB/results/workflow/45/Tandem2PepXML_/O08-10105_c.mzXML.pep.xml


i get following error:


---------------------------------------------
/usr/local/apps/tpp/bin/xinteract (TPP v4.3 JETSTREAM rev 1, Build
200909181208 (linux))

running: "/usr/local/apps/tpp/bin/InteractParser
'/IMSB/results/workflow/45/Xinteract_/Xinteract.pep.xml'
'/IMSB/results/workflow/45/Tandem2PepXML_/O08-10105_c.mzXML.pep.xml' -L'7'"
file 1: /IMSB/results/workflow/45/Tandem2PepXML_/O08-10105_c.mzXML.pep.xml
processed altogether 1290 results


results written to file
/IMSB/results/workflow/45/Xinteract_/Xinteract.pep.shtml



command completed in 0 sec
running: "/usr/local/apps/tpp/bin/PeptideProphetParser
'/IMSB/results/workflow/45/Xinteract_/Xinteract.pep.xml' DECOY=DECOY_
ACCMASS LEAVE PI INSTRWARN"
using Accurate Mass Bins
using pI
Using no error on different instrument types.
Using Decoy Label "DECOY_".
(X! Tandem)
WARNING: Found unanticipated cleavage in refinement mode.  Turning off NTT
model.
adding Accurate Mass mixture distr
adding pI mixture distr
init with X! Tandem trypsin MS Instrument info: Manufacturer:
ThermoFinnigan, Model: LTQ Orbitrap XL, Ionization: ESI, Analyzer: ITMS,
Detector: EMT

PeptideProphet  (TPP v4.3 JETSTREAM rev 1, Build 200909181208 (linux))
akel...@isb
read in 0 1+, 1135 2+, 137 3+, 18 4+, 0 5+, 0 6+, and 0 7+ spectra.
Initialising statistical models ...
Iterations: .........10.........20.......
WARNING: Mixture model quality test failed for charge (2+).
WARNING: Mixture model quality test failed for charge (3+).
model complete after 28 iterations
command completed in 1 sec
running: "/usr/local/apps/tpp/bin/ProphetModels.pl -i
/IMSB/results/workflow/45/Xinteract_/Xinteract.pep.xml"
Analyzing /IMSB/results/workflow/45/Xinteract_/Xinteract.pep.xml ...
Reading Accurate Mass Model model +1 ...
Reading kernel density calc pI [pI] model +1 ...
Reading Accurate Mass Model model +2 ...
Reading kernel density calc pI [pI] model +2 ...
Reading Accurate Mass Model model +3 ...
Reading kernel density calc pI [pI] model +3 ...
Reading Accurate Mass Model model +4 ...
Reading kernel density calc pI [pI] model +4 ...
Reading Accurate Mass Model model +5 ...
Reading kernel density calc pI [pI] model +5 ...
Reading Accurate Mass Model model +6 ...
Reading kernel density calc pI [pI] model +6 ...
Reading Accurate Mass Model model +7 ...
Reading kernel density calc pI [pI] model +7 ...
Parsing search results "/IMSB/scratch/andreas/O08-10105_c (X! Tandem)"...
 => Total of 0 hits.
Warning: empty y range [0:0], adjusting to [0:1]
Warning: empty y range [0:0], adjusting to [0:1]

plot "/IMSB/results/workflow/45/Xinteract_/Xinteract.pep_PPPROB.tsv" using
2:1 title "PeptideProphet" with line  lc 2  , x notitle with line lt 0 lc -1


^
"/IMSB/results/workflow/45/Xinteract_/Xinteract.pep_PPPROB.gp", line 16:
warning: Skipping data file with no valid points

plot "/IMSB/results/workflow/45/Xinteract_/Xinteract.pep_IPPROB.tsv" using
2:1 title "iProphet" with line  lc 2  , x notitle with line lt 0 lc -1

^
"/IMSB/results/workflow/45/Xinteract_/Xinteract.pep_IPPROB.gp", line 16:
warning: Skipping data file with no valid points
command completed in 0 sec
running: "/usr/local/apps/tpp/bin/DatabaseParser
'/IMSB/results/workflow/45/Xinteract_/Xinteract.pep.xml'"
command completed in 0 sec
running: "/usr/local/apps/tpp/bin/RefreshParser
'/IMSB/results/workflow/45/Xinteract_/Xinteract.pep.xml'
'/IMSB/data/databases/uniprot/sp_9606.fasta'"
 - Building Commentz-Walter keyword tree...  - Searching the tree...
 - Linking duplicate entries...  - Printing results...

command completed in 1 sec
running: "/usr/local/apps/tpp/cgi-bin/PepXMLViewer.cgi -I
/IMSB/results/workflow/45/Xinteract_/Xinteract.pep.xml"
Segmentation fault

command "/usr/local/apps/tpp/cgi-bin/PepXMLViewer.cgi -I
/IMSB/results/workflow/45/Xinteract_/Xinteract.pep.xml" exited with non-zero
exit code: 35584
QUIT - the job is incomplete
---------------------------------------


can someone explain me what the error code means and what i am doing wrong?

p.s.

i played a little bit around with the parameter but get always the same
error message.
i also checked the output of the xtandem run (contains over 1000 valid
models) and also the pep.xml (which is valid).




-- 
Andreas Quandt, PhD
Institute of Molecular Systems Biology
Swiss Federal Institute of Technology Zurich (ETH)
Wolfgang-Pauli-Str. 16
ETH Hönggerberg, HPT D 76
CH-8093 Zürich

Tel:  +41 44 633 3449
Fax:  +41 44 633 1051
Mobil:+41 78 899 5206 E-mail: [email protected]

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