hi brian,

many thanks for looking into it!
i also tried to process the file with different options but always the same
error.
it would be awesome if you (or natalie) could test the uploaded files
(andreasquandt_090918.zip) as i otherwise do not know how to solve this
problem :-(.

cheers,
andreas


On Fri, Sep 18, 2009 at 7:20 PM, Brian Pratt <[email protected]>wrote:

> My guess is its nothing you're doing wrong - iProphet is still pretty new
> and it's probably confusing the PepXMLViewer parser.  If you can upload the
> file that crashed pepXMLViewer to ftp://insilicos.serveftp.net/pub I
> Natalie or I will be happy to have a look.
>
> Brian
>
> On Fri, Sep 18, 2009 at 6:47 AM, Andreas Quandt 
> <[email protected]>wrote:
>
>> dear list,
>>
>>
>> when running following command (tpp 4.3.1)
>>
>> /usr/local/apps/tpp/bin/xinteract
>> -N/IMSB/results/workflow/45/Xinteract_/Xinteract.pep.xml -dDECOY_ -OAlIwp
>> /IMSB/results/workflow/45/Tandem2PepXML_/O08-10105_c.mzXML.pep.xml
>>
>>
>> i get following error:
>>
>>
>> ---------------------------------------------
>> /usr/local/apps/tpp/bin/xinteract (TPP v4.3 JETSTREAM rev 1, Build
>> 200909181208 (linux))
>>
>> running: "/usr/local/apps/tpp/bin/InteractParser
>> '/IMSB/results/workflow/45/Xinteract_/Xinteract.pep.xml'
>> '/IMSB/results/workflow/45/Tandem2PepXML_/O08-10105_c.mzXML.pep.xml' -L'7'"
>> file 1: /IMSB/results/workflow/45/Tandem2PepXML_/O08-10105_c.mzXML.pep.xml
>>
>> processed altogether 1290 results
>>
>>
>> results written to file
>> /IMSB/results/workflow/45/Xinteract_/Xinteract.pep.shtml
>>
>>
>>
>> command completed in 0 sec
>> running: "/usr/local/apps/tpp/bin/PeptideProphetParser
>> '/IMSB/results/workflow/45/Xinteract_/Xinteract.pep.xml' DECOY=DECOY_
>> ACCMASS LEAVE PI INSTRWARN"
>> using Accurate Mass Bins
>> using pI
>> Using no error on different instrument types.
>> Using Decoy Label "DECOY_".
>> (X! Tandem)
>> WARNING: Found unanticipated cleavage in refinement mode.  Turning off NTT
>> model.
>> adding Accurate Mass mixture distr
>> adding pI mixture distr
>> init with X! Tandem trypsin MS Instrument info: Manufacturer:
>> ThermoFinnigan, Model: LTQ Orbitrap XL, Ionization: ESI, Analyzer: ITMS,
>> Detector: EMT
>>
>> PeptideProphet  (TPP v4.3 JETSTREAM rev 1, Build 200909181208 (linux))
>> akel...@isb
>> read in 0 1+, 1135 2+, 137 3+, 18 4+, 0 5+, 0 6+, and 0 7+ spectra.
>> Initialising statistical models ...
>> Iterations: .........10.........20.......
>> WARNING: Mixture model quality test failed for charge (2+).
>> WARNING: Mixture model quality test failed for charge (3+).
>> model complete after 28 iterations
>> command completed in 1 sec
>> running: "/usr/local/apps/tpp/bin/ProphetModels.pl -i
>> /IMSB/results/workflow/45/Xinteract_/Xinteract.pep.xml"
>> Analyzing /IMSB/results/workflow/45/Xinteract_/Xinteract.pep.xml ...
>> Reading Accurate Mass Model model +1 ...
>> Reading kernel density calc pI [pI] model +1 ...
>> Reading Accurate Mass Model model +2 ...
>> Reading kernel density calc pI [pI] model +2 ...
>> Reading Accurate Mass Model model +3 ...
>> Reading kernel density calc pI [pI] model +3 ...
>> Reading Accurate Mass Model model +4 ...
>> Reading kernel density calc pI [pI] model +4 ...
>> Reading Accurate Mass Model model +5 ...
>> Reading kernel density calc pI [pI] model +5 ...
>> Reading Accurate Mass Model model +6 ...
>> Reading kernel density calc pI [pI] model +6 ...
>> Reading Accurate Mass Model model +7 ...
>> Reading kernel density calc pI [pI] model +7 ...
>> Parsing search results "/IMSB/scratch/andreas/O08-10105_c (X! Tandem)"...
>>  => Total of 0 hits.
>> Warning: empty y range [0:0], adjusting to [0:1]
>> Warning: empty y range [0:0], adjusting to [0:1]
>>
>> plot "/IMSB/results/workflow/45/Xinteract_/Xinteract.pep_PPPROB.tsv" using
>> 2:1 title "PeptideProphet" with line  lc 2  , x notitle with line lt 0 lc -1
>>
>>
>> ^
>> "/IMSB/results/workflow/45/Xinteract_/Xinteract.pep_PPPROB.gp<http://xinteract.pep_ppprob.gp/>",
>> line 16: warning: Skipping data file with no valid points
>>
>> plot "/IMSB/results/workflow/45/Xinteract_/Xinteract.pep_IPPROB.tsv" using
>> 2:1 title "iProphet" with line  lc 2  , x notitle with line lt 0 lc -1
>>
>> ^
>> "/IMSB/results/workflow/45/Xinteract_/Xinteract.pep_IPPROB.gp<http://xinteract.pep_ipprob.gp/>",
>> line 16: warning: Skipping data file with no valid points
>> command completed in 0 sec
>> running: "/usr/local/apps/tpp/bin/DatabaseParser
>> '/IMSB/results/workflow/45/Xinteract_/Xinteract.pep.xml'"
>> command completed in 0 sec
>> running: "/usr/local/apps/tpp/bin/RefreshParser
>> '/IMSB/results/workflow/45/Xinteract_/Xinteract.pep.xml'
>> '/IMSB/data/databases/uniprot/sp_9606.fasta'"
>>  - Building Commentz-Walter keyword tree...  - Searching the tree...
>>  - Linking duplicate entries...  - Printing results...
>>
>> command completed in 1 sec
>> running: "/usr/local/apps/tpp/cgi-bin/PepXMLViewer.cgi -I
>> /IMSB/results/workflow/45/Xinteract_/Xinteract.pep.xml"
>> Segmentation fault
>>
>> command "/usr/local/apps/tpp/cgi-bin/PepXMLViewer.cgi -I
>> /IMSB/results/workflow/45/Xinteract_/Xinteract.pep.xml" exited with non-zero
>> exit code: 35584
>> QUIT - the job is incomplete
>> ---------------------------------------
>>
>>
>> can someone explain me what the error code means and what i am doing
>> wrong?
>>
>> p.s.
>>
>> i played a little bit around with the parameter but get always the same
>> error message.
>> i also checked the output of the xtandem run (contains over 1000 valid
>> models) and also the pep.xml (which is valid).
>>
>>
>>
>>
>> --
>> Andreas Quandt, PhD
>> Institute of Molecular Systems Biology
>> Swiss Federal Institute of Technology Zurich (ETH)
>> Wolfgang-Pauli-Str. 16
>> ETH Hönggerberg, HPT D 76
>> CH-8093 Zürich
>>
>> Tel:  +41 44 633 3449
>> Fax:  +41 44 633 1051
>> Mobil:+41 78 899 5206 E-mail: [email protected]
>>
>>
>> >>
>>

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