Hi there,
we recently installed TPP (v4.3 JETSTREAM rev 1, Build 200909091257
(MinGW)) on a Windows XP (SP2 machine). The data we're analysing is
generated on an ABI/SCIEX QStar, which we've converted into mzXML
using mzwiff.

The mzXML data converts fine in TPP (using the Tandem analysis
pipeline) and the database search works fine on the resulting *.tandem
file. We're able to convert these files into *.pepXML format and view
them in the PepXML Viewer without any problem.

We're unable however to analyse the *.pepXML data using XInteract.
We'd like to run PeptideProphet then ProteinProphet, but each time we
do the following error is generated:

********************************************************************************************************************
run_in c:/Inetpub/wwwroot/ISB/data; c:\Inetpub\tpp-bin\xinteract  -
Ninteract.pep.xml -p0.05 -l7 -O c:/Inetpub/wwwroot/ISB/data/
6hrs_Control_Dupl1-s1.tandem.pep.xml
--------------------------------------------------------------------------------

***********

c:\Inetpub\tpp-bin\xinteract (TPP v4.3 JETSTREAM rev 1, Build
200909091257 (MinGW))

running: "C:/Inetpub/tpp-bin/InteractParser "interact.pep.xml" "c:/
Inetpub/wwwroot/ISB/data/6hrs_Control_Dupl1-s1.tandem.pep.xml" -L"7""
 file 1: c:/Inetpub/wwwroot/ISB/data/6hrs_Control_Dupl1-
s1.tandem.pep.xml
 processed altogether 3278 results


 results written to file c:/Inetpub/wwwroot/ISB/data/interact.pep.xml

 direct your browser to http://localhost/ISB/data/interact.pep.shtml


command completed in 1 sec

running: "C:/Inetpub/tpp-bin/PeptideProphetParser "interact.pep.xml"
MINPROB=0.05"
 (X! Tandem (k-score))
init with X! Tandem (k-score) trypsin
MS Instrument info: Manufacturer: ABI / SCIEX, Model: unknown,
Ionization: ESI, Analyzer: TOFMS, Detector: unknown


--------------------------------------------------------------------------------
...skipping 20 lines of output...
--------------------------------------------------------------------------------

  => Total of 0 hits.
command completed in 0 sec

running: "C:/Inetpub/tpp-bin/DatabaseParser "interact.pep.xml""
command completed in 0 sec

running: "C:/Inetpub/tpp-bin/RefreshParser "interact.pep.xml" "c:/
Inetpub/wwwroot/ISB/data/PfalciparumAnnotatedProteins61.fasta""
  - Searching the tree...
  - Linking duplicate entries...  - Printing results...

  - Building Commentz-Walter keyword tree...command completed in 1
sec

running: "c:/Inetpub/wwwroot/../tpp-bin/PepXMLViewer.cgi -I c:/Inetpub/
wwwroot/ISB/data/interact.pep.xml"

command "c:/Inetpub/wwwroot/../tpp-bin/PepXMLViewer.cgi -I c:/Inetpub/
wwwroot/ISB/data/interact.pep.xml" failed: Unknown error

command "c:/Inetpub/wwwroot/../tpp-bin/PepXMLViewer.cgi -I c:/Inetpub/
wwwroot/ISB/data/interact.pep.xml" exited with non-zero exit code:
-1073741819
QUIT - the job is incomplete

command "c:\Inetpub\tpp-bin\xinteract -Ninteract.pep.xml -p0.05 -l7 -O
c:/Inetpub/wwwroot/ISB/data/6hrs_Control_Dupl1-s1.tandem.pep.xml"
failed: Unknown error

*******************************************************************************************************************************

Is anyone able to assist in establishing what the problem is, and the
best solution to follow? If need be we can ftp the error files
generated by the command, or an example *.pepXML data file (<4Mb).

Thanks in advance

Tabo

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