The relevant line is "=> Total of 0 hits."  Take a look at the
interact.pep.xml file and see if there really are any results with
>0.05 probability values.  It's possible that while the search did
complete without error, the input comes from a bad sample, or the
search parameters may not be set correctly (wrong database used, etc).

Natalie



On Fri, Oct 2, 2009 at 12:29 AM, Tabo <[email protected]> wrote:
>
> Hi there,
> we recently installed TPP (v4.3 JETSTREAM rev 1, Build 200909091257
> (MinGW)) on a Windows XP (SP2 machine). The data we're analysing is
> generated on an ABI/SCIEX QStar, which we've converted into mzXML
> using mzwiff.
>
> The mzXML data converts fine in TPP (using the Tandem analysis
> pipeline) and the database search works fine on the resulting *.tandem
> file. We're able to convert these files into *.pepXML format and view
> them in the PepXML Viewer without any problem.
>
> We're unable however to analyse the *.pepXML data using XInteract.
> We'd like to run PeptideProphet then ProteinProphet, but each time we
> do the following error is generated:
>
> ********************************************************************************************************************
> run_in c:/Inetpub/wwwroot/ISB/data; c:\Inetpub\tpp-bin\xinteract  -
> Ninteract.pep.xml -p0.05 -l7 -O c:/Inetpub/wwwroot/ISB/data/
> 6hrs_Control_Dupl1-s1.tandem.pep.xml
> --------------------------------------------------------------------------------
>
> ***********
>
> c:\Inetpub\tpp-bin\xinteract (TPP v4.3 JETSTREAM rev 1, Build
> 200909091257 (MinGW))
>
> running: "C:/Inetpub/tpp-bin/InteractParser "interact.pep.xml" "c:/
> Inetpub/wwwroot/ISB/data/6hrs_Control_Dupl1-s1.tandem.pep.xml" -L"7""
>  file 1: c:/Inetpub/wwwroot/ISB/data/6hrs_Control_Dupl1-
> s1.tandem.pep.xml
>  processed altogether 3278 results
>
>
>  results written to file c:/Inetpub/wwwroot/ISB/data/interact.pep.xml
>
>  direct your browser to http://localhost/ISB/data/interact.pep.shtml
>
>
> command completed in 1 sec
>
> running: "C:/Inetpub/tpp-bin/PeptideProphetParser "interact.pep.xml"
> MINPROB=0.05"
>  (X! Tandem (k-score))
> init with X! Tandem (k-score) trypsin
> MS Instrument info: Manufacturer: ABI / SCIEX, Model: unknown,
> Ionization: ESI, Analyzer: TOFMS, Detector: unknown
>
>
> --------------------------------------------------------------------------------
> ...skipping 20 lines of output...
> --------------------------------------------------------------------------------
>
>  => Total of 0 hits.
> command completed in 0 sec
>
> running: "C:/Inetpub/tpp-bin/DatabaseParser "interact.pep.xml""
> command completed in 0 sec
>
> running: "C:/Inetpub/tpp-bin/RefreshParser "interact.pep.xml" "c:/
> Inetpub/wwwroot/ISB/data/PfalciparumAnnotatedProteins61.fasta""
>  - Searching the tree...
>  - Linking duplicate entries...  - Printing results...
>
>  - Building Commentz-Walter keyword tree...command completed in 1
> sec
>
> running: "c:/Inetpub/wwwroot/../tpp-bin/PepXMLViewer.cgi -I c:/Inetpub/
> wwwroot/ISB/data/interact.pep.xml"
>
> command "c:/Inetpub/wwwroot/../tpp-bin/PepXMLViewer.cgi -I c:/Inetpub/
> wwwroot/ISB/data/interact.pep.xml" failed: Unknown error
>
> command "c:/Inetpub/wwwroot/../tpp-bin/PepXMLViewer.cgi -I c:/Inetpub/
> wwwroot/ISB/data/interact.pep.xml" exited with non-zero exit code:
> -1073741819
> QUIT - the job is incomplete
>
> command "c:\Inetpub\tpp-bin\xinteract -Ninteract.pep.xml -p0.05 -l7 -O
> c:/Inetpub/wwwroot/ISB/data/6hrs_Control_Dupl1-s1.tandem.pep.xml"
> failed: Unknown error
>
> *******************************************************************************************************************************
>
> Is anyone able to assist in establishing what the problem is, and the
> best solution to follow? If need be we can ftp the error files
> generated by the command, or an example *.pepXML data file (<4Mb).
>
> Thanks in advance
>
> Tabo
>
> >
>

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