Looks like you're taking search results analyzed on a different system
(likely linux based) and trying to analyze on your windows box.  Part
of the analysis goes back to the original sequence database to map
peptides to proteins.  As you can see in your error message, that
sequence database originally existed in /home/ruse database/ which
does not exist on your PC.  One fix is to place the sequence database
on your computer and make sure to update the database reference in all
input files (that is search for and replace
/home/ruse/database/IPI_v3.64_contaminants.RS.fasta with whatever the
new full path is).

On Wed, Apr 28, 2010 at 10:34 AM, Cristian <[email protected]> wrote:
> Hi All,
> After running Peptide Prophet, I get the error message pasted below. I
> updated the database paths and I still get the following error.  Could
> you suggest a fix for this error message?
>
> Thanks a lot,
> Cristian
>
> running: "C:/Inetpub/tpp-bin/DatabaseParser "interact.pep.xml""
> command completed in 3 sec
>
> running: "C:/Inetpub/tpp-bin/RefreshParser "interact.pep.xml" "/home/
> ruse/database/IPI_v3.64_contaminants.RS.fasta""
>  - Searching the tree...error: could not open database file "/home/
> ruse/database/IPI_v3.64_contaminants.RS.fasta" (No such file or
> directory)
>  - Building Commentz-Walter keyword tree...
> command "C:/Inetpub/tpp-bin/RefreshParser "interact.pep.xml" "/home/
> ruse/database/IPI_v3.64_contaminants.RS.fasta"" failed: Unknown error
>
> command "C:/Inetpub/tpp-bin/RefreshParser "interact.pep.xml" "/home/
> ruse/database/IPI_v3.64_contaminants.RS.fasta"" exited with non-zero
> exit code: -1
> QUIT - the job is incomplete
>
>
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