Matt,Gavin, thanks for the quick reply,

Matt,
I meant to say lockmass filter (function in Waters terms), it is not a 
separate scan event, I just turned it on to improve mass accuracy, all the 
scans were MS1, but Thermo decided to mix the two filters together,
I am using ReAdW to convert o mzXML as I need centroid data, an option 
deleted by Thermo from Exactive and can`t find support for it in msconvert,
here is an example of a working (lockmass off) and a corrupted  file 
(converted by ReAdW)
it`s certainly a Thermo bug, msconvert is not the culprit :), 

Gavin, 
No switching, a single polarity data, 


https://icseclzt.cc.ic.ac.uk/pickup.php?claimID=YZ6QXbK3ojWU3z9D&claimPasscode=ufAeKModjUaB3ZFH&emailAddr=mkamleh%40imperial.ac.uk


On Thursday, November 1, 2012 4:08:04 PM UTC+1, matt.chambers wrote:
>
> Hi Anas, 
>
> I don't know what a "lockmass function" is in the context of a Thermo 
> instrument. Do you have it set 
> up as a separate scan event? I thought lockmass was calibrated based on 
> finding the given masses 
> inside normal MS1 scans. Msconvert will certainly export ALL scan events 
> by default, so if XCMS 
> isn't picking some of them up that's not an msconvert bug. :) If you WANT 
> to export just certain 
> scan events, use the scanEvent filter: 
>
> # skip scan event 5 
> --filter "scanEvent 1-4 6-" 
>
> Hope this helps, 
> -Matt 
>
>
> On 11/1/2012 9:57 AM, Anas wrote: 
> > Hi all, 
> > How did this problem got solved eventually ? I have acquired Q-Exactive 
> data with lockmass on (for 
> > metabolomics uses) and the lockmass functions seems the only one to be 
> recognized by xcms, 
> > I appreciate your help, 
> > Cheers, 
> > Anas 
> > 
> > On Friday, June 25, 2010 11:36:27 PM UTC+2, Matt Chambers wrote: 
> > 
> >       Hi Andris and Charlie, 
> > 
> >     Overdue support for filter lines found in Exactive files has finally 
> been added to ProteoWizard 
> >     (as of r2087). Also there was a problem with parsing the 
> >     instrument model and that should also be fixed. 
> > 
> >     Thanks for your reports and for uploading the files. 
> >     -Matt 
> > 
> >     On 6/24/2010 3:46 PM, Zhenyu Chang wrote: 
> >     However, I have encountered the following problem when using 
> msconvert tool. I was trying to 
> >     convert a .RAW data generated by Thermo Fisher Exactive instrument 
> >     to mzML 1.1 data format. 
> > 
> > 
> >     On 11/17/2009 3:19 AM, Andris Jankevics wrote: 
> >      > Hi Matt. 
> >      > 
> >      > Thank you for your work, these data will be mostly metabolomics 
> data 
> >      > sets which will be analyzed by XCMS and several other software 
> tools. 
> >      > It would be nice to have functionality in ReAdW to extract only 
> mzXML 
> >      > file by based on scan event (for example only lock mass corrected 
> >      > positive slice), but this is not so essential. 
> >      > 
> >      > best regards, 
> >      > Andris 
> >      > 
> >      > On Mon, Nov 16, 2009 at 8:36 PM, Matthew Chambers 
> >      > <[email protected] <javascript:>>  wrote: 
> >      >> That file requires Xcalibur 2.1, which doesn't run on Windows 7 
> x64...I 
> >      >> had to use a Windows VM to view it. It indeed appears they've 
> put scan 
> >      >> segment and scan event in the filter line, and have added a new 
> keyword 
> >      >> ("lock"). The lock keyword appears to only be applied if at 
> least one of 
> >      >> the configured lock masses was found in the spectrum, in which 
> case some 
> >      >> adjustment has been applied; otherwise, it won't have the lock 
> keyword 
> >      >> and no adjustment is applied. It shouldn't be difficult to add 
> support 
> >      >> for these changes, although I'm curious what you're planning to 
> do with 
> >      >> this data once it's in mzXML format. 
> >      >> 
> >      >> -Matt 
> > 
> > 
> > 
> > 
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>

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