Hello,

 

I work in a mass spectrometry data analysis lab. We recently acquired an 
orbitrap  and I would like to use qualscore on these data. I transformed my 
.raw file  to mzxml without any compression, I ran the xtandem identification 
algorithm and then the peptideProphet algorithm. I use a min prob threshold of 
0 in peptide Prophet to keep all the spectra in the analyses.

Then I use qualscore on the interact.pep.xml file created :

*java -jar -Xmx1500m c:\Inetpub\tpp-bin\qualscore.jar -c 1.0 -p 0.1 -l –a 
file_interact.pep.xml*

The program seems to work fine (see log file joined) but I only get NaN as 
result for all values. (see joined file)

 

Could you tell me what I did wrong or how to solve the problem?

 

Thanks for your help

 

Delphine

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C:\Inetpub\wwwroot\ISB\data\300_19_01_130329>java -jar -Xmx1500m 
        c:\Inetpub\tpp-bin\qualscore.jar -c 1.0 -p 0.1 -l -a 
300_19_01_f1p1ns_130402_01_0_interact.pep.xml
QualScore version 1.0_2 Copyright (C) 2006
Institute for Systems Biology, Seattle WA
QualScore is free software and comes with absolutely no warranty.

XML
Loading interact data:
  1000  2000  3000  4000  5000  6000  7000  8000  9000  10000  11000  12000  130
00  14000  15000  16000  17000  18000  19000  20000  21000  21238
Interact data file contains 21237 entries.
0 +1 were removed.
Enumerating scans:
  processing 300_19_01_F1P1NS_130402_01.mzXML...     500 1000 1500 2000 2500 300
0 3500 4000 4500 5000 5500 6000 6500 7000 7500 8000 8500 9000 9500 10000 10500 1
1000 11500 12000 12500 13000 13500 14000 14500 15000 15500 16000 16500 17000 175
00 18000 18500 19000 19500 20000 20500 21000 21237
Features calculated for:  21237 (477637 ms)
Training set:  837/19001 (good/bad)
Unassigned spectra:  19332
Quality score calculation time: 188 ms
Writing classifier co-efficients to file:       
300_19_01_f1p1ns_130402_01_0_interact.pep.xml.all.qual.coef
21237 spectra written to 
'300_19_01_f1p1ns_130402_01_0_interact.pep.xml.all.qual'.
Time:   483

Attachment: 300_19_01_F1P1NS_130402_01_0_interact.pep.xml.all.qual.coef
Description: Binary data

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