Hello!

I have a problem with running peptide/protein prophet. Below, you can find an 
error message. I havent got this problem previously. I have run so far many 
files, but now, there are some which dint want to be processed. The search with 
tandem is correct, I havnet got any messaage. Now, the interact.pep.xml is 
created, but is empty and interact.prot.xml is not created. Any idea what can 
be wrong?

thanks!

c:\Inetpub\tpp-bin\xinteract (TPP v4.6 OCCUPY rev 3, Build 201307241109 (MinGW))

running: "C:/Inetpub/tpp-bin/InteractParser "M5.interact.pep.xml" 
"M5.tandem.pep.xml" -I -L"6""
 file 1: M5.tandem.pep.xml
SUCCESS: CORRECTED data file c:/Inetpub/wwwroot/ISB/data/Membrane/M5.mzML in 
msms_run_summary tag ...
Unknown file type. No file loaded.
 processed altogether 53699 results
INFO: Results written to file: 
c:/Inetpub/wwwroot/ISB/data/Membrane/M5.interact.pep.xml
command completed in 168 sec 

running: "C:/Inetpub/tpp-bin/DatabaseParser "M5.interact.pep.xml""
command completed in 0 sec 

running: "C:/Inetpub/tpp-bin/RefreshParser "M5.interact.pep.xml" 
"c:/Inetpub/wwwroot/ISB/data/dbase/BCaRun_301013/CONCAT_Uniprot_reviewed_human_301013.fasta""
  - Searching the tree...
  - Linking duplicate entries...  - Printing results...

  - Building Commentz-Walter keyword tree...command completed in 23 sec 

running: "C:/Inetpub/tpp-bin/PeptideProphetParser "M5.interact.pep.xml" 
MINPROB=0.05 ACCMASS DECOY=DECOY_"
using Accurate Mass Bins
Using Decoy Label "DECOY_".
 (X! Tandem (k-score))
adding Accurate Mass mixture distr
init with X! Tandem (k-score) trypsin 
MS Instrument info: Manufacturer: Thermo Scientific, Model: UNKNOWN, 
Ionization: nanoelectrospray, Analyzer: orbitrap, Detector: inductive detector

 PeptideProphet  (TPP v4.6 OCCUPY rev 3, Build 201307241109 (MinGW)) AKeller@ISB
 read in 0 1+, 33305 2+, 17324 3+, 2755 4+, 312 5+, 0 6+, and 0 7+ spectra.
Initialising statistical models ...
Found 26821 Decoys, and 26875 Non-Decoys
Iterations: .........10.........20.........
WARNING: Mixture model quality test failed for charge (2+).
WARNING: Mixture model quality test failed for charge (3+).
WARNING: Mixture model quality test failed for charge (4+).
WARNING: Mixture model quality test failed for charge (5+).
model complete after 30 iterations
command completed in 105 sec 

running: "C:/Inetpub/tpp-bin/ProphetModels.pl -i M5.interact.pep.xml -d 
"DECOY_""
Analyzing M5.interact.pep.xml ...
Reading Accurate Mass Model model +1 ...
Reading Accurate Mass Model model +2 ...
Reading Accurate Mass Model model +3 ...
Reading Accurate Mass Model model +4 ...
Reading Accurate Mass Model model +5 ...
Reading Accurate Mass Model model +6 ...
Reading Accurate Mass Model model +7 ...
Parsing search results "c:/Inetpub/wwwroot/ISB/data/Membrane/M5 (X! Tandem 
(k-score))"...
  => Found 0 hits. (0 decoys, 0 excluded)
  => Total so far: 0 hits. (0 decoys, 0 excluded)
The system cannot find the path specified.
command completed in 1 sec 

running: "c:/Inetpub/wwwroot/../tpp-bin/PepXMLViewer.cgi -I 
c:/Inetpub/wwwroot/ISB/data/Membrane/M5.interact.pep.xml"

command "c:/Inetpub/wwwroot/../tpp-bin/PepXMLViewer.cgi -I 
c:/Inetpub/wwwroot/ISB/data/Membrane/M5.interact.pep.xml" failed: Unknown error

command "c:/Inetpub/wwwroot/../tpp-bin/PepXMLViewer.cgi -I 
c:/Inetpub/wwwroot/ISB/data/Membrane/M5.interact.pep.xml" exited with non-zero 
exit code: -1073741819
QUIT - the job is incomplete

command "c:\Inetpub\tpp-bin\xinteract -NM5.interact.pep.xml -p0.05 -l6 -PREC 
-OApu -dDECOY_ M5.tandem.pep.xml" failed: Unknown error

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