Dear TPP developers and users,

I took the the new Comet in TPP 4.7 (POLAR VORTEX) out for spin, but keep 
getting errors like "Error - 
CometMemMgr::CometMemAlloc(pdTmpFastXcorrData[1374])" and "Operation not 
permitted" when searching an mzXML made from some 5 GB Orbitrap E. coli 
data. This mzXML file works fine with both X!Tandem and SpectraST. To get a 
parameter file, I created one with "comet -p". 

When I search a tiny mzXML file with one MS1 and three MS2 spectra I 
created myself, it works, and I get reasonable results. But I have tried it 
with reasonably small ion trap datasets of <100 MB, I get the errors as for 
the 5 GB Orbi data.

Any suggestions? Should I allocate more memory to comet somewhere?


Cheers,

Magnus

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