Hi Jimmy,

Many thanks - the "spectrum_batch_size" trick worked! Are the results (e.g. 
the expectation values) dependent on the batch size?


Cheers,

Magnus

On Monday, 3 March 2014 19:05:21 UTC+1, Jimmy Eng wrote:
>
> Mangus,
>
> There's something broken with our latest Comet 2013.02 rev. 2 release 
> under Windows.  We attempted to address large memory search performance, 
> which appeared to work fine in our limited testing, but we definitely broke 
> something else in the process and are actively working on addressing this 
> issue now.  
>
> The current suggested work-around would be:
> a).  make use of the "spectrum_batch_size" parameter; set it to some 
> value, say 3000 or 5000 to allow you to process your data by searching 
> smaller batches of spectra at a time
> b).  revert the Comet binary to the previous 2013.02 rev. 1 release.
>
> - Jimmy
>
>
> On Mon, Mar 3, 2014 at 9:46 AM, [email protected] <javascript:> <
> [email protected] <javascript:>> wrote:
>
>> Dear TPP developers and users,
>>
>> I took the the new Comet in TPP 4.7 (POLAR VORTEX) out for spin, but keep 
>> getting errors like "Error - 
>> CometMemMgr::CometMemAlloc(pdTmpFastXcorrData[1374])" and "Operation not 
>> permitted" when searching an mzXML made from some 5 GB Orbitrap E. coli 
>> data. This mzXML file works fine with both X!Tandem and SpectraST. To get a 
>> parameter file, I created one with "comet -p". 
>>
>> When I search a tiny mzXML file with one MS1 and three MS2 spectra I 
>> created myself, it works, and I get reasonable results. But I have tried it 
>> with reasonably small ion trap datasets of <100 MB, I get the errors as for 
>> the 5 GB Orbi data.
>>
>> Any suggestions? Should I allocate more memory to comet somewhere?
>>
>>
>> Cheers,
>>
>> Magnus
>>
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