Hi,

I tried to convert the data generated by a MALDI-TOFTOF with iTRAQ 8plex 
labeling into mzXML and went through the pipeline. The database search 
using tandem seemed working. However, I couldn't use the generated  
tandem.pep.xml file to go through peptideprophet with the Libra function 
turned on. (It seemed working okay without Libra) Below was what I got:

c:\Inetpub\tpp-bin\xinteract (TPP v4.7 POLAR VORTEX rev 1, Build 201405141849 
(MinGW))
 PPM mode in Accurate Mass Model ...

running: "C:/Inetpub/tpp-bin/InteractParser "Cyto_1-3_Libra_interact.pep.xml" 
"Cytosol_OGF1_3_1.tandem.pep.xml" -L"1""
 file 1: Cytosol_OGF1_3_1.tandem.pep.xml
SUCCESS: CORRECTED data file c:/Inetpub/wwwroot/ISB/data/Cytosol_OGF1_3_1.mzXML 
in msms_run_summary tag ...
 processed altogether 1910 results
INFO: Results written to file: 
c:/Inetpub/wwwroot/ISB/data/Cyto_1-3_Libra_interact.pep.xml
command completed in 1 sec 

running: "C:/Inetpub/tpp-bin/DatabaseParser "Cyto_1-3_Libra_interact.pep.xml""
command completed in 0 sec 

running: "C:/Inetpub/tpp-bin/RefreshParser "Cyto_1-3_Libra_interact.pep.xml" 
"c:/Inetpub/wwwroot/ISB/data/parameters/Uniprot_sprot_human_mouse_2014.fasta""
  - Searching the tree...
  - Linking duplicate entries...  - Printing results...

  - Building Commentz-Walter keyword tree...command completed in 5 sec 

running: "C:/Inetpub/tpp-bin/PeptideProphetParser 
"Cyto_1-3_Libra_interact.pep.xml" MINPROB=0.05 PPM MALDI"
using PPM mass difference
maldi mode
 (X! Tandem (k-score))
init with X! Tandem (k-score) trypsin 
MS Instrument info: Manufacturer: AB SCIEX, Model: TOF/TOF 5800, Ionization: 
matrix-assisted laser desorption ionization, Analyzer: time-of-flight, 
Detector: microchannel plate detector

 PeptideProphet  (TPP v4.7 POLAR VORTEX rev 1, Build 201405141849 (MinGW)) 
AKeller@ISB
 read in 1910 1+, 0 2+, 0 3+, 0 4+, 0 5+, 0 6+, and 0 7+ spectra.

command "C:/Inetpub/tpp-bin/PeptideProphetParser 
"Cyto_1-3_Libra_interact.pep.xml" MINPROB=0.05 PPM MALDI" failed: Unknown error

command "C:/Inetpub/tpp-bin/PeptideProphetParser 
"Cyto_1-3_Libra_interact.pep.xml" MINPROB=0.05 PPM MALDI" exited with non-zero 
exit code: 255
QUIT - the job is incomplete

command "c:\Inetpub\tpp-bin\xinteract -NCyto_1-3_Libra_interact.pep.xml -p0.05 
-l1 -PPM -Om -Lcondition.xml-1 Cytosol_OGF1_3_1.tandem.pep.xml" failed: Unknown 
error

*Command FAILED*
RETURN CODE:65280

Is there anything I should modify on the settings?

Thanks,

Chloe

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