Hello TPP team,

At this time, I'm using TPP for iTRAQ quantitation after a search with 
X!Tandem.

I'm facing some problems  with the duration of the search. In my case, I 
use 1 static modification and I'd like to include seven others potential 
modifications.
With only one static and one or two potential, it's quite faste (around 
20-30 min on my system 2 processors, 8 virtual cores). As soon as I 
increase the number of potential modif the duration increase dramatically. 
Did you observe such issue ? If not, do you use a refinement search ?

I'm wondering if it's only a matter of power of my computer or if it's 
rather due to X!Tandem algorithm.

Thanks in advance for any advice.

Fred 

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