The best thing to do is to investigate the model plots to make sure that 
the results look accurate. In my experience, MSGF+ tends to be somewhat 
overaggressive and will assign peptides to some spectra that are clearly 
incorrect. This is usually corrected or eliminated if the results are 
combined with those of a second search engine (e.g. Comet) and processed 
with iProphet.

On Thursday, February 19, 2015 at 2:49:16 AM UTC-8, Florian wrote:
>
> Hej. 
> Thanks for the comment. I analyzed my data with MSGF+ and the result looks 
> fine. I am just concerned that if I want to publish data which were 
> analyzed combining MSGF+ and TPP, I will get problems. So, could the TPP 
> developers please comment on the warning? Is it planned to thoroughly test 
> the MSGF+ any time soon? 
>

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