Hi There,
 
Very few spectra below that score 15-20 only. Yes, that's my own data. I 
will surely familiarize myself with X!Tandem usage. Will update you very 
soon. Thanks for help
 

On Thursday, 18 January 2018 12:02:01 UTC+5:30, Luis wrote:

> Hello,
>
> How did you determine the quality of the XTandem results?  How many 
> spectra do you get below an Expect score of 0.01?  Is this your own data?
>
> As for the parameters, you very likely will want to change the default 
> values that are included in TPP, and that may be the reason for the 
> observed discrepancies with Comet.  I suggest that you familiarize yourself 
> with XTandem usage by going to the XTandem/GPM website. 
>
> Cheers,
> --Luis
>
>
> On Wed, Jan 17, 2018 at 8:00 PM, Vipul Batra <[email protected] 
> <javascript:>> wrote:
>
>> Hello Luis,
>>  
>> Thank you so much for your reply. The results from X!Tandem search seem 
>> fine to me. I understand that the quality may be poor, however, I have just 
>> changed the pipeline to TANDEM. I have used the same RAW files on Comet and 
>> got good results. The PARAMS file is the one by default. I have not changed 
>> it. Is TANDEM more sensitive than COMET? I mean that It sees the same data 
>> as bad which Comet had no problem in processing. 
>>  
>>
>> On Wednesday, 17 January 2018 01:14:46 UTC+5:30, Luis wrote:
>>
>>> Hello,
>>>
>>> Can you verify if you are getting any decent results from your XTandem 
>>> search?  (i.e. open SAMPLE1.tandem.pep.xml in the PepXMLViewer and 
>>> examine.)  The warnings that you see are indicative of either poor data 
>>> quality, or bad search parameters, so you will want to check those as well.
>>>
>>> Cheers,
>>> --Luis
>>>
>>>
>>> On Mon, Jan 15, 2018 at 7:48 PM, Vipul Batra <[email protected]> 
>>> wrote:
>>>
>>>>
>>>> On Saturday, 13 January 2018 19:59:06 UTC+5:30, Vipul Batra wrote:
>>>>>
>>>>> I am getting this error : "*Command FAILED * RETURN CODE:65280" every 
>>>>> time I am using X!tandem. I have used the same database and mzml files 
>>>>> with 
>>>>> comet and the commands were successfully run, however, there seems to be 
>>>>> an 
>>>>> issue with X! TANDEM. I have even tried with different databases e.g. 
>>>>> bovine, human, bubalis but no go . Please guide. 
>>>>>
>>>>  
>>>> Iterations: .........10.........20......
>>>> WARNING: Mixture model quality test failed for charge (2+).
>>>> WARNING: Mixture model quality test failed for charge (3+).
>>>> WARNING: Mixture model quality test failed for charge (4+).
>>>> WARNING: Mixture model quality test failed for charge (5+).
>>>> model complete after 27 iterations
>>>> command completed in 2 sec 
>>>>
>>>> running: "E:/TPP/bin/ProphetModels.pl -i 
>>>> /tmp/a06808/params/interact.pep.xml" 
>>>> Analyzing /tmp/a06808/params/interact.pep.xml ...
>>>> Parsing search results "e:/TPP/data/raw/SAMPLE1 (X! Tandem 
>>>> (k-score))"...
>>>>   => Found 0 hits. (0 decoys, 0 excluded)
>>>>   => Total so far: 0 hits. (0 decoys, 0 excluded)
>>>> command completed in 0 sec 
>>>> moving tempfile /tmp/a06808/params/interact.pep.xml to interact.pep.xml
>>>>
>>>> running: "E:/TPP/cgi-bin/PepXMLViewer.cgi -I /tmp/a06808/params/
>>>> interact.pep.xml.a06808" 
>>>> command "E:/TPP/cgi-bin/PepXMLViewer.cgi -I /tmp/a06808/params/
>>>> interact.pep.xml.a06808" failed: Unknown error
>>>>
>>>> command "E:/TPP/cgi-bin/PepXMLViewer.cgi -I /tmp/a06808/params/
>>>> interact.pep.xml.a06808" exited with non-zero exit code: 255
>>>> QUIT - the job is incomplete
>>>>
>>>>  
>>>>
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>>>
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