David,

We have done many comparisons. You should be getting very similar results 
when performing closed searches.
You can post questions on MSFragger here:
https://github.com/chhh/MSFragger-GUI/issues

Also, are you using the latest version? 
You can get the latest version of MSFragger here:
http://msfragger.arsci.com/upgrader/

Best,
Alexey Nesvizhskii

On Tuesday, May 22, 2018 at 12:40:51 PM UTC-4, David Zhao wrote:
>
> Hi there,
>
> We've started to evaluate MsFragger tool, has anybody done a comparison 
> between Comet and MsFragger? Is it complementary to Comet? We've run a 
> couple of MsFragger searches, using parameters converted from comet 
> parameters, it seems MsFragger is focusing more on finding more PTMs, which 
> results in many long peptide hits, and overriding charge option doesn't 
> seem to be working...
>
> Any inputs or comments is greatly appreciated!
> Thanks,
>
> David
>

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