Hi Mike,
Thanks a lot. I am able to use percolator now in TPP.
I have one more query regarding Kojak - If I am not wrong, PeptideProphet
can work even without Decoy using the learned model of correct and
incorrect assignment. Does it work for search results of Kojak as well. I
tried both (with and without Decoy) ways and I got completely different
results. I could run both of them successfully. However, in case of
"without Decoy" I am getting around 2,500 cross linked peptides at 1% FDR.
In the other case (with Decoy), I am getting hardly 15-20 peptides.

Please suggest the needful.

Thanks & Regards
-Kamal

On Thu, Sep 27, 2018 at 2:28 PM Michael Hoopmann <
[email protected]> wrote:

> Hi Kamal,
>
> Yes, you can use PeptideProphet to validate Kojak results. Select “Kojak”
> from your pipeline in the upper right of the TPP page, and it will default
> PeptideProphet parameters for Kojak. Input is the PepXML output from Kojak.
>
>
>
> The windows version of Percolator can be found here:
> https://github.com/percolator/percolator/releases
>
> To use it in the TPP do the following:
>
> 1.      Install Percolator on your computer.
>
> 2.      Go into the Percolator bin folder (usually something like
> C:\Program Files\Percolator\bin\) and copy percolator.exe
>
> 3.      Paste it into your TPP bin folder (usually something like
> C:\TPP\bin\)
>
> 4.      In the TPP, select “External Tools->Percolator” from the menu.
> Input is the .perc.txt output files from Kojak.
>
>
>
> Cheers,
>
> Mike
>
>
>
> *From:* [email protected] [mailto:
> [email protected]] *On Behalf Of *Kamal Mandal
> *Sent:* Thursday, September 27, 2018 12:17 PM
> *To:* spctools-discuss
> *Subject:* [spctools-discuss] Kojak
>
>
>
> Hello,
>
> Is it possible to use PeptideProphet for validation of data (Cross-linked
> peptides) obtained from Kojak search in TPP.
>
> Is the windows version of percolator available and how do we integrate
> that to TPP suite?
>
>
>
> Thanks,
>
>
>
> -Kamal
>
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-- 
Kamal Mandal, M.Tech
Research Scholar
National Institute of Immunology, New Delhi
Aruna Asaf Ali Marg
New Delhi - 110067
*India*

*Contact no. :- +91- 9560445356 *

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