Hello all,

I'm having trouble running TPP 5.2 in general in Ubuntu 18.04. I followed 
the compilation guideline, and after using svn checkout -r 7922 (as 
recommended by Eric)  it went ahead, although I still have some things that 
are broken, like checking for the ions in the pepxml file. I get the 
following error:

Error - scan 10000 is an *MS1* scan in the mzXML file 
> /home/laptop/Documents/TPP_data/tests/QuickYeastUPS1/UPS1_50000amol_R1.mzML


I can click on the Spectrum and see the peptide table but whenever I click 
on the ions I see that error.

More importantly, I can run Comet followed by PeptideProphet, iProphet and 
ProteinProphet and it all goes fine. I can do the same with MSGF+ 
(PeptideProphet, iProphet and ProteinProphet). However, when I try to 
combine both PeptideProphet files (from Comet and MSGF+) I always get the 
following error:


*EXECUTING: cd /home/laptop/Documents/TPP_data/TH129_134/comsgf ; 
/usr/local/tpp/bin/InterProphetParser 
/home/laptop/Documents/TPP_data/TH129_134/Comet/interact_comet.pep.xml 
/home/laptop/Documents/TPP_data/TH129_134/MSGF/interact_p005.pep.xml 
interact.ipro.pep.xml *

Running FPKM NSS NRS NSE NSI NSM NSP Model EM:
Computing NSS values ... 

Creating 1 threads 
Wait for threads to finish ...
.... done
Computing NRS values ... 

Creating 1 threads 
Wait for threads to finish ...
0--------------------------------------------------50------------------------------------------------100%
.....................................................................................................
 done
Computing NSE values ... 

Creating 1 threads 
Wait for threads to finish ...
0--------------------------------------------------50------------------------------------------------100%
.....................................................................................................
 done
Computing NSI values ... 

Creating 1 threads 
Wait for threads to finish ...
0--------------------------------------------------50------------------------------------------------100%
.....................................................................................................
 done
Computing NSM values ... 

Creating 1 threads 
Wait for threads to finish ...
0--------------------------------------------------50------------------------------------------------100%
.....................................................................................................
 done
Computing NSP values ... 
Creating 1 threads 
Wait for threads to finish ...
0--------------------------------------------------50------------------------------------------------100%
.....................................................................................................
 done
FPKM values are unavailable ... 
Iterations: DEBUG HERE ...
Segmentation fault (core dumped)


*Command FAILED*
RETURN CODE:35584 

I have tried to disable FPKM, but gives the same error. Odd is that I can 
run iProphet on each and runs fine, including FPKM.

My samples are dimethylated samples, and was searched using static 
modifications, doing one search for Light and one search for Heavy, and 
then both files combined with PeptideProphet., like so:
*xinteract -Ninteract_comet.pep.xml -p0.05 -l7 -PPM -OAPd -dDECOY 
H_TH189.pep.xml L_TH189.pep.xml *
I have also tried using -p0 but gives in the end the same error when 
combining both search engines. 

In TPP 5.1 the combination works, however I'm trying to use the new Xpress 
which uses the intensity for quantitation, and in TPP 5.1 the intensities 
are not passed to the proteins.

Any help would be appreciated. Thanks,

Alejandro

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