Hi Alex,

It looks like you are running an unofficial version of the code that
obviously has a few issues with this data and has aged by this point.  If
you can share your input data I can try the latest version of the code and
see if that works or provide a solution in the near future?

Cheers,
-David

On Tue, Jan 28, 2020 at 8:57 AM Alex Zelter <[email protected]> wrote:

> I'm running into the following error when trying to use xinteract to
> process Kojak 2.0 results.
> The command I'm running is:
> /usr/local/tpp/bin/xinteract -Ninteract.pep.xml -p0 -l1 -eT
> -D/path/to/database.fasta -PPM -OAPdp -drandom_ -ip ./kojak-output.pep.xml
>
> INFO: Processing xl MixtureModel ...
>  PeptideProphet  (TPP v5.2.1-dev Flammagenitus, Build 201908090730-7945
> (Linux-x86_64)) AKeller@ISB
>  read in 0 1+, 34 2+, 11290 3+, 7625 4+, 2948 5+, 874 6+, and 13 7+
> spectra.
> Initialising statistical models ...
> Found 13541 Decoys, and 9243 Non-Decoys
> Iterations: DEBUG HERE ...
> ERROR: nan detected in NonParametricDistribution ...
>
> command "/usr/local/tpp/bin/PeptideProphetParser 'interact.pep.xml'
> MINPROB=0 PPM ACCMASS NONPARAM DECOYPROBS DECOY=random_" exited with
> non-zero exit code: 256
> QUIT - the job is incomplete
>
> This was previously working for me using TPP v5.2.0-b1 Flammagenitus
> Pre-release Beta, Build 201809101205-7809 (Linux-x86_64))
>
> INFO: Processing xl MixtureModel ...
>  PeptideProphet  (TPP v5.2.0-b1 Flammagenitus Pre-release Beta, Build
> 201809101205-7809 (Linux-x86_64)) AKeller@ISB
>  read in 0 1+, 34 2+, 11290 3+, 7625 4+, 2948 5+, 874 6+, and 13 7+
> spectra.
> Initialising statistical models ...
> Found 13541 Decoys, and 9243 Non-Decoys
> Iterations: .........10.........20......
> WARNING: Mixture model quality test failed for charge (1+).
> WARNING: Mixture model quality test failed for charge (2+).
> WARNING: Mixture model quality test failed for charge (7+).
> model complete after 27 iterations
> INFO: Processing loop MixtureModel ...
>
> etc.
>
> If anyone has any ideas why I am running into this error with the new
> build I'd be very grateful!
> Thanks!
> Alex
>
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