Hi Alastair,

There is a much newer version of tpp2mzid in our current release candidates of 
TPP version 6. I’m hoping that the error messages have been resolved in this 
new version. However, I also need the fasta search database file to run the 
conversion with the newer tpp2mzid. Could you also provide a link to that file 
and I will finish my tests and let you know the result?

Thanks,

Mike

 

From: 'Alastair Skeffington' via spctools-discuss 
<[email protected]> 
Sent: Monday, June 21, 2021 6:45 AM
To: spctools-discuss <[email protected]>
Subject: [spctools-discuss] tpp2mzid help - 'no peptide evidence found ...'

 

I'm at the end of a multi-year odyssey of a project, and I just need to submit 
data to PRIDE.

 

Unfortunately, when I run tpp2mzid for some prot.xml files, I get an error such 
as this:

 

Warning (A), no peptide evidence found for (mod): EENAFVQKIAE from Br20418.t2

 

This only happens for some prot.xml files, but I'm not sure why. The pep.xml 
files from which the prot.xml are derived convert fine.

 

I've put an example here: https://we.tl/t-Z9qNNjDC0k

 

I was running TPP via the docker container: digitalproteomes/tpp:version-5.2.0.1

 

Here is the stdout in full:

Reading: HCLC_EhN.prot.xml

Reading: /data/HCLC_EhN_ipro.pep.xml

Unknown xx modification: B = 114.535 42.5515

Unknown xx modification: J = 113.084 44.0023

Unknown xx modification: O = 237.148 80.0613

Unknown xx modification: U = 150.954 6.13277

Unknown xx modification: X = 111 46.0864

Unknown xx modification: Z = 128.551 28.5358

Unknown xx modification: B = 114.535 42.5515

Unknown xx modification: J = 113.084 44.0023

Unknown xx modification: O = 237.148 80.0613

Unknown xx modification: U = 150.954 6.13277

Unknown xx modification: X = 111 46.0864

Unknown xx modification: Z = 128.551 28.5358

Unknown xx modification: B = 114.535 42.5515

Unknown xx modification: J = 113.084 44.0023

Unknown xx modification: O = 237.148 80.0613

Unknown xx modification: U = 150.954 6.13277

Unknown xx modification: X = 111 46.0864

Unknown xx modification: Z = 128.551 28.5358

Unknown xx modification: B = 114.535 42.5515

Unknown xx modification: J = 113.084 44.0023

Unknown xx modification: O = 237.148 80.0613

Unknown xx modification: U = 150.954 6.13277

Unknown xx modification: X = 111 46.0864

Unknown xx modification: Z = 128.551 28.5358

Unknown xx modification: B = 114.535 42.5515

Unknown xx modification: J = 113.084 44.0023

Unknown xx modification: O = 237.148 80.0613

Unknown xx modification: U = 150.954 6.13277

Unknown xx modification: X = 111 46.0864

Unknown xx modification: Z = 128.551 28.5358

Unknown xx modification: B = 114.535 42.5515

Unknown xx modification: J = 113.084 44.0023

Unknown xx modification: O = 237.148 80.0613

Unknown xx modification: U = 150.954 6.13277

Unknown xx modification: X = 111 46.0864

Unknown xx modification: Z = 128.551 28.5358

Unknown xx modification: B = 114.535 42.5515

Unknown xx modification: J = 113.084 44.0023

Unknown xx modification: O = 237.148 80.0613

Unknown xx modification: U = 150.954 6.13277

Unknown xx modification: X = 111 46.0864

Unknown xx modification: Z = 128.551 28.5358

Unknown xx modification: B = 114.535 42.5515

Unknown xx modification: J = 113.084 44.0023

Unknown xx modification: O = 237.148 80.0613

Unknown xx modification: U = 150.954 6.13277

Unknown xx modification: X = 111 46.0864

Unknown xx modification: Z = 128.551 28.5358

17648 psms read.

Warning (A), no peptide evidence found for (mod): EENAFVQKIAE from Br20418.t2

 

Help would be very much appreciated!

Thanks,

Alastair

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