Hi Mike,

With Kojak data the peptide length is meaningless and recorded as zero in
the pepXML.  The default parameters of xinteract use min peptide length of
7 which invalidates all results in this file.  You have to run with min
peptide length of zero when processing Kojak data: xinteract -l0

Cheers!
-David

On Mon, Nov 14, 2022 at 5:06 PM Michael Riffle <[email protected]> wrote:

> Greetings TPP folks,
>
> I just pulled the latest Docker image and am trying to run the Kojak then
> PeptideProphet. Kojak runs fine, PeptideProphet produces an error. Here is
> my output:
>
> ```
> sudo docker run -v `pwd`:/data spctools/tpp xinteract
> QEHFX_2019_0510_AZ_034_eh220_comet.pep.xml
>
> xinteract (TPP v6.1.0 Parhelion, Build 202206071715-8676 (Linux-x86_64))
>
> running: "/usr/local/tpp/bin/InteractParser 'interact.pep.xml'
> 'QEHFX_2019_0510_AZ_034_eh220_comet.pep.xml' -L'7'"
>  file 1: QEHFX_2019_0510_AZ_034_eh220_comet.pep.xml
>  processed altogether 77134 results
> INFO: Results written to file: /data/interact.pep.xml
> command completed in 5 sec
>
> running: "/usr/local/tpp/bin/DatabaseParser 'interact.pep.xml'"
> command completed in 1 sec
>
> running: "/usr/local/tpp/bin/RefreshParser 'interact.pep.xml'
> '/data/EH217_3pepCnt_plusRev.fasta'"
> enzyme name is:trypsin
>   - Building Commentz-Walter keyword tree...
>   - Searching the tree...
>   - Linking duplicate entries...
>   - Printing results...
>   - Mapped 42490 entries
>
> command completed in 3 sec
>  using MAXEHFX_2019_0510_AZ_034_eh220_comet.pep.xml for PeptideProphet...
>
> running: "/usr/local/tpp/bin/PeptideProphetParser 'interact.pep.xml'"
>  (Kojak)
> init with Kojak trypsin
> init Loop model with Kojak trypsin
> adding XLSecondScoreFraction mixture distribution
> adding XLTopExpectScore mixture distribution
> init XL model with Kojak trypsin
>  PeptideProphet  (TPP v6.1.0 Parhelion, Build 202206071715-8676
> (Linux-x86_64)) AKeller@ISB
>  read in 0 1+, 0 2+, 0 3+, 0 4+, 0 5+, 0 6+, and 0 7+ spectra.
>  read in no data
> MS Instrument info: Manufacturer: UNKNOWN, Model: UNKNOWN, Ionization:
> UNKNOWN, Analyzer: UNKNOWN, Detector: UNKNOWN
>
> INFO: Processing xl MixtureModel ...
>
> command "/usr/local/tpp/bin/PeptideProphetParser 'interact.pep.xml'"
> exited with non-zero exit code: 256
> QUIT - the job is incomplete
> ```
>
> I suspect the "read no data" line above, towards the end, is the culprit,
> but I can't guess what might be causing that. Do you have any ideas?
>
> Thanks,
> Mike Riffle
>
>
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