Can anyone help me with this, please?

On Monday, July 31, 2023 at 11:39:47 PM UTC+5:30 Debojyoti Pal wrote:

> Dear all
>
> I am quantifying an iTRAQ run, where one of the channel seems to be having 
> lower intensity across the board (around 20%).  I am thinking of the TIC 
> normalization (total intensity), but it is mentioned as "not recommended" 
> in LIBRA settings. 
>
> Why is it so? If I am mixing equal labelled peptide, what is wrong in TIC, 
> assuming one of the peptides labeled poorly?  What is the alternative here 
> if that is not suitable? 
>
> Why is it so? If I am mixing equal labelled peptide, what is wrong in TIC, 
> assuming one of the peptides labeled poorly?  What is the alternative here 
> if that is not suitable?
>
> *Also,* *Can I see the total intensity of each channel somewhere?*
>
> Regards
> Debojyoti
>

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