On 9 Nov 2015, at 3:21pm, Brice Andr? <brice.andre at ams-solutions.be> wrote:

> So, does someone has an idea on what can cause such performance issues on
> some sqlite DB requests ?

Since you

1) are getting delays and not errors, and
2) you are using very common OS and hardware, and
3) you are accessing a database from an internal disk,

I strongly suspect that any fault is not in SQLite.  From experience this sort 
of problem is caused by either

A) an anti-virus package or
B) a hard disk which is just starting to fail and will get worst until it fails 
completely

Diagnosis and fixes should relate to trying a different disk or temporarily 
disabling the anti-virus software, not to anything inside SQLite.

Simon.

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