Excuse the off topic but when I read this I was truly amazed.
http://www.reformation.org/variola.html
Kirk

Also see http://www.whale.to/a/campbell2.html

 RŽsumŽ of Experiments on Variola.

By CHARLES A. R. CAMPBELL, M. D.

San Antonio, Texas.


Mr. President and Members of the Bexar County Medical Society:

There must be some motive for a member of the same professional household to
keep in the background such a work as I am about to present for your
consideration this evening. This motive is that I hoped some avenue might
present itself permitting me to continue the work to the point of carrying
out further experiments to such a degree of scientific certainty as would
place it beyond the possibility of contradiction. It was my ambition to go
into Mexico, where, with knowledge of the language and customs of the
people, I could have obtained the cooperation of the "powers that be," and
of the medical profession, and could there have completed the investigation.
There never was a doubt in mind that I could have had this cooperation, as
it was freely offered to me from that country, but the lack of finance was
the insuperable barrier.

As it is now my intention to publish this work, though I do not know when or
where, I desire out of respect to my home professional brothers and home
society to present it to you first.

The work of the Eradication of Malaria by the Cultivation of Bats, The
Mosquitoes' Natural Enemy and Destroyer, on which I have been engaged, as
you are all aware, for the past twenty years, is more important and
far-reaching in its benefits to mankind than this work, and I purpose for
the rest of my days to concentrate all of my energies, spare time, and money
on the continued studies of that most benevolent, though misunderstood
creature, the common bat.

I desire to return thanks before this Society to my good friend, Dr. W. L.
Barker, who, appreciating my endeavors, had me placed in charge of the Pest
House, where I found opportunities of pursuing this research on smallpox,
which I could not have had without his kindly intervention. I also owe my
thanks to Mr. Thomas Patino, my head nurse, who is a highly valued employee
and most kind and sympathetic to the unfortunates under his care.

The papers in the order of their presentation are, "Resume of Experiments on
Variola," "My Observations of Bed Bugs," and Dr. John Watts' valuable work
and observations on this disease, which he presents under the caption of
"Eradication of Smallpox without Vaccination or Disinfection." The author
made Dr. Watts thoroughly acquainted with the result of his smallpox-bedbug
investigation, on account of the Doctor's going to locate in Mexico, where
the disease is so common, and requested him to continue the work in that
country, on the lines indicated in the above mentioned papers. How well he
carried on the investigation his paper will tell.

Some years ago, while traveling in Mexico, I learned that the Mexican
mothers of the lower classes find a great deal of consolation when their
children have had the small pox. They regard it as inevitable; and, in order
to get through with this trouble as soon as possible, they place the well
children upon the same bed as the one having the smallpox, so that they may
become infected with the disease.

I was also told by these lowly people that those who sleep on the outside of
the houses, upon nothing more, perhaps, than a sheep's skin or raw hide cot
or bed, usually escape the disease -- hence the mother places the children
who are well upon the same bed with the sick ones. This information was kept
in mind by me until I had occasion to see a few cases in the City of San
Antonio, Texas. In considering this malady, I quickly became impressed with
two distinctive peculiarities of it, viz: Its being a disease of the winter
and of the coldest climates, and that, as a rule, it is confined to the
lower or filthy classes.

Having followed very closely the current literature concerning the brilliant
work done by Drs. Reed, Carroll, and Agramonte in yellow fever, the above
peculiarities caused me hypothetically to ascribe to the bedbug the quality
of being the diffusing agent of variola. (As to the bedbug's power of
resistance to intense cold, water, and starvation, see my "Observation on
Bedbugs.")

Assuming that bedbugs are the only diffusing agents of this loathsome
disease, then our present knowledge of its being "air-borne," or of its
being transmitted by fomites, must be all wrong, therefore the principal
work here mentioned is the demonstration of its non-contagiousness by means
of clothing, bedding, hangings --in short, fomites.

I then began to experiment with this disease directly by contact and to
expose some person to it who had not had it. I selected as this person one
whose movements I could at all times control and understand, and, therefore,
I chose myself. As even the air itself, without contact, is considered
sufficient to convey this disease, and touching the clothes of a smallpox
patient considered equivalent to contracting it, I exposed myself with the
same impunity as my pest-house keeper, who is immune, having had the
smallpox. After numerous exposures, made in the ordinary manner, by going
from house to house where the disease was and demanding, under legal
authority, the removal of the patients, as well as members of the family, to
the pest house, I have never conveyed this disease to my family, or to any
of my patients or friends, although I did not disinfect myself or my clothes
nor take any precautions whatever, except to be sure that no bedbugs got
about my clothing.

Another one of my experiments was thoroughly to beat a rug in a room, only
eight or ten feet square, from which had just been removed a smallpox
patient. This rug had been given to the negro family in question by a white
person after his family had utilized it until it was useless for them, and
thereafter it had been used for years by the said negro family. I beat this
rug in the room until the air was stifling, and remained therein for thirty
minutes. This represented the respiratory as well as the digestive systems
as accepted avenues of infection. While I was exposing my person to this
experiment of inhaling particles of organic, as well as micro-organic,
matter, I never lost sight of the fact that I was engaged in trifling with
the system of knowledge which had been handed down from generation to
generation, each one accepting as true what the preceding one had written. I
also remembered that, if such men as composed the scientific expedition to
Cuba for the investigation of yellow fever had adhered to the old-time and
accepted theories that bedding, carpets, clothing, hangings -- in short
fomites --were the conveyors of yellow fever, we would not now have the
knowledge which these gentlemen so nobly acquired and generously gave to the
public in the interest of mankind, consequently I continued my experiments.
After inhaling the dust from that rug, I examined my sputum microscopically
the following morning and found cotton and woolen fibres, pollen, and
comminuted manure, as also bacteria of many kinds.

Convinced that I had given my respiratory and digestive systems ample
opportunities to afford avenues of infection, from that time on I mingled
freely with my family, patients, and friends; but, for the first fourteen
days after the experiment of beating the rug and inhaling the dust, I slept
in my office for fear of conveying the disease to my family.

The next experiment was the exposure of two city carpenters, two laborers,
and myself. Three of these men had never been vaccinated, and the fourth
only in infancy. This experiment consisted in tearing down an old privy at
the detention camp or pest house, which privy had been used four or five
years by smallpox patients only. It was constructed of 1 x 12 inch slats and
boards. With hatchets and levers the old structure was soon razed; and the
foul-smelling lumber was carried by each of us a distance of one hundred
yards and neatly re-constructed.

As the day was very hot and our water supply some distance from the work, I
placed a bucket of water about ten feet from the work and in such a
direction with the wind that the dust from the sawing and nailing of the old
boards would fall into the water. Of course, the laborers did not observe my
object in so doing, and they and myself all drank freely of the water till
noon. After dinner all of us worked on that foul-smelling structure and
drank of that same water till 'evening, when the work was completed. None of
us ever felt any bad effects from our exposure. I had these men under my
observation for fourteen days after this 'experiment.

In five instances where the disease made its appearance in the homes of
negro washerwomen, I found two and three weeks' washing laundered and ready
to be delivered to the owners. It is a matter of common knowledge that negro
washerwomen, when ironing clothes, place them upon beds to keep them from
becoming wrinkled, and these articles of clothing, when discovered in an
infected house, are generally burned by the health authorities, the owners
being reimbursed from public funds; but in each of the above instances I
took the clothes to the pest-house grounds, and, spreading them upon the
grass, I carefully searched each piece of clothing for bugs. Not being able
to find any bedbugs on any piece, I returned all the clothing to the owners
without any disinfection whatever. These clothes did not convey the disease
to anyone. Anita H., a Mexican child, four years of age, never vaccinated
and who had never had the disease, was taken to the pest house, where she
took a baby out of the crib and played with it about four hours, hugging and
kissing it and riding it in a perambulator around the grounds; but, although
this baby was covered with pustules of smallpox, and although we took no
precautions whatever (the girl's mother having agreed to this experiment),
the girl did not acquire the disease.

J. C., brought to the pest house in a vesicular stage, made an uneventful
recovery after passing through the typical states. In this case I caused the
bed clothes of his bed to be undisturbed when he recovered. This same bed,
without any change in the bed clothes, was then occupied by L. M. This
individual had never been vaccinated nor had smallpox, and understood that
he occupied this bed as an experiment. He did not acquire the disease.

P. H., a Mexican, vaccinated in infancy, who freely mingled with the
smallpox patients in the discharge of his duties as night watchman at the
pest house, keeping up the fires and remaining all night, did not contract
the disease.

A. C., decidedly strumous, never vaccinated nor had the smallpox, freely
mingled with smallpox patients in all of the stages, playing cards with
them, eating and sleeping in the infected tents, and has continued to do so
for more than two years.

Mrs. T. P., wife of the Pest-House keeper, aged26, vaccinated in infancy,
acts as nurse and cook and freely mingles with the female patients.

Master E. P., and sister, aged respectively eleven and nine, the former
vaccinated nine years ago, the latter unsuccessfully, play with children in
all of the stages of smallpox and play with the toys of the little patients,
without the least harm.

Personally, I have not only come into direct contact with smallpox patients
many times, but have taken off and rubbed my outer clothes on the beds of
the patients and then returned to the city and mingled freely with my
family, friends, and patients, without disinfecting at all.

In one instance, which I believe is worthy of special mention, a man, his
wife, and four children were here, and three of these children became
infected with the smallpox. I took all of them to the Pest House, and as all
of them preferred to stay in one room, I placed them together. The man and
his wife had previously had the disease, and only one child escaped it. I
kept them at the Pest House until the eighteenth day after the period of
desquamation on the part of the case developing last. They were returned
home upon a Saturday morning. Observe that this child, although living in
the same room with the patients at the Pest House, had not acquired the
smallpox, after being exposed to it all of the time for a period of six
weeks; yet upon the fifth day after returning home, this child acquired the
initial fever. I then examined their house and found it to be literally
alive with bedbugs.

In addition to these experiments, it should be remembered that I had at the
Pest House half a dozen employees, who washed, scrubbed tents, 'etc., and
these persons were employed by me especially because they were non-immune --
and yet none of them ever contracted the disease.

Among some of the cases coming under my observation and care, which did not
originate here, is the following. The patient, a girl of eleven years, had a
fairly-developed case, and was at one of our hotels. I took this patient and
her father and mother to the Pest House, in the meantime locking the door of
the room at the hotel and leaving orders that no one be allowed to enter it
until my return. This room had been occupied two days and nights by the
patient. Upon my return I carefully inspected the bed and the entire room,
particularly the walls and ceiling, and not finding any bedbugs, I told the
hotel proprietor that the room was again all right; and it was from that
time on occupied. All of the occupants were kept under careful observation,
but not a case developed in any of the persons occupying the room.

Another case was that of a little girl who was seized by the disease in
Mexico about eight hours before reaching San Antonio. This little patient's
family consisted of her father, mother, and little brother, eight years old.
I took them all (under protest) to the Pest House. The man I allowed to
leave and go to the city and return, as he pleased; and, with my consent, he
procured -a horse and buggy from a livery stable and took his wife riding
every day. At night they went to the theatre, returning to the Pest House to
sleep. He also bought a doll for the little girl; and she played with it,
being at the time thoroughly covered with smallpox. She made a dress for
this doll, slept with it at night, kissed it, and played with it
continually, until about the fourth day, when she became displeased with it;
and after some consultation, her father returned it to the store where it
was purchased, and exchanged it for a larger doll. The clerk from whom the
purchase was made was kept under secret observation for a long time, but
nothing developed from the exchange.

A woman, returning from Mexico, stopped over in Eagle Pass to rest, as the
"small of her back was nearly breaking in two;" she placed a plaster on her
back to obtain relief, resuming her journey the next day. A day or two after
her arrival in San Antonio she developed smallpox and was taken to the Pest
House. The day being cold and the Pest House some distance from her room,
she sent out and bought a fine blanket to cover herself on the road, using
it as a shawl. On arriving at the Pest House, the room being nicely heated,
she took the blanket off, placed it on a chair,and got into bed. One of the
attendants overheard the keeper's wife ask her husband to bring her from the
city a new blanket for their new baby, three weeks old. When he left the
Pest House to get this patient, thinking the new blanket was the one
intended for the new baby, he folded it up and brought it to the keeper's
wife, who proceeded to wrap up her baby snugly in it. The mistake was not
discovered for one week-yet the baby did not acquire the disease.

In the case of the woman, it is curious to note that the area of skin
covered by the plaster already referred to, which had been left on the
patient's back, was not attacked by the disease, the underlying skin
remaining perfectly normal, although there was not a half inch square on her
body that was not marked by the disease.

After making a great many of those experiments at the Pest House (it may be
well to say that I had previously destroyed all the bedbugs) I procured a
large flag-pole, with a large yellow flag, and made the occasion of the
planting of the pole and the flag-raising a little feast-afternoon, with a
banquet, to which were invited the City Council and the officers of the City
Government. Liquid and solid refreshments were served, speech-making was
indulged in, laudatory of the experiments, by some of the aldermen and other
officials present, who knew well of the work I was doing. Evidently they
must have had some faith in it, when they so gladly came to a Pest House
(and almost in direct contact with smallpox patients) to attend a banquet
and honor me by their presence. Some eighteen or twenty.,attended and
remained two or three hours; one alderman in particular, who had never been
vaccinated or had the disease, came in direct contact with a patient whose
body was covered with the characteristic eruptions.

The most important observation on the medical aspect of this disease is the
caehexia with which it is invariably associated and which is actually the
soil requisite for its different degrees of virulence. I refer to the
scorbutic cachexia. Among the lower -classes of people this particular
acquired constitutional perversion of nutrition is most prevalent, primarily
on account of their poverty, but also because of the fact that they care
little or nothing for fruits or vegetables. That a most intimate connection
exists between variola and scorbutus is evidenced by the fact that it is
most prevalent among the poor or filthy class of people; that it is more
prevalent in winter, when the anti-scorbutics are scarce and high priced;
and, finally, that the removal of this perversion of nutrition will so
mitigate the virulence of this malady as positively to prevent the pitting
or pocking of smallpox.

A failure of the fruit crop in any particularly large area is always
followed the succeeding winter by the presence of smallpox. My experience is
limited to eighty-eight cases of that disease in the Pest-House, and my
attention has constantly been directed to the establishing of the fact of
the non-contagiousness of fomites and to the prevention of the pitting or
pocking by the malady. That the pitting or pocking can be positively
prevented I am absolutely certain, for in the above number of cases I had
only one patient who became pocked and this was done intentionally. In all
of the cases of smallpox that have originated here I have always found
bedbugs; and where patients suffering with this disease were brought here
and placed in premises free from these vermin, the disease did not spread to
persons living with the patient. This has occurred in many cases, and in all
stages of the disease.



"Disinfection" tent at San Antonio Pest House. The only disinfection done
was to look for bedbugs in the clothing of the patients or those to be held
in detention.


The deluxe quarters of the Pest House: author's horse and buggy.




Rows of tents for persons held in detention on account of having been
exposed to smallpox.



Ambulance House, Feed Room, and Stable, connected with the San Antonio Pest
House.

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