http://www.nytimes.com/2002/06/05/science/05PART.html?ex=1023940800&en 
=e5f0f8e505ec0911&ei=5040&partner=MOREOVER

Data Revised on Soot in Air and Deaths
By ANDREW C. REVKIN

Revisiting their own data with new methods, scientists who conducted 
influential studies that linked sooty air pollution with higher death 
rates have lowered their estimate of the risk posed by bad-air days.

The findings do not challenge what is now a well-established link 
between air pollution and premature death. But the new analysis is 
highly likely to delay the final review of new regulations on 
small-particle pollution, officials of the Environmental Protection 
Agency said yesterday.

The review was projected to end, and the new rules to take effect, by 
the end of next year.

"This may clearly push it beyond that," a spokesman for the E.P.A., 
Joe Martyak, said last night.

The fine particles in question come mainly from power plants and 
diesel engines, and the proposed rules have been at the center of a 
long legal, political and public-relations battle between private 
environmental groups and power plant owner and vehicle manufacturers.

The researchers, at the Johns Hopkins University, have been 
distributing their new analysis to scientists and government 
officials by fax and e-mail. Yesterday, they set up a Web site, 
biosun01.biostat.jhsph.edu /~fdominic/research.html, that details 
their new findings.

"This is a very important finding that needs to be probed," said 
Daniel S. Greenbaum, president of the Health Effects Institute, the 
organization that paid for the work and that was created by the 
E.P.A. and industry to conduct unbiased studies on contentious 
pollution issues.

The studies in question, using data from 1987 to 1994, analyzed 
day-to-day small-particle pollution in 90 American cities and 
compared them to the death rates among the 100 million residents of 
those cities, accounting for other influences on mortality like 
weather and time of year.

They found a pattern of more deaths, notably deaths from heart and 
lung problems, in the days after spikes in the concentrations of 
particles smaller than 10 microns, particles that can be deeply 
inhaled into the lungs and stay there. In the original analysis, the 
rise was 0.4 percent above the typical mortality rate for each jump 
of 10 micrograms of soot per cubic meter of air. In the new analysis, 
the increase is half that.

The researchers said the change was small but significant. The 
average level in the average city is now about 24 micrograms a cubic 
meter.

The work has been published for several years in a variety of leading 
journals like The New England Journal of Medicine and The American 
Journal of Epidemiology. The project, the National Morbidity, 
Mortality and Air Pollution Study, was given extra weight by policy 
makers because of the reputation of the Health Effects Institute and 
the Johns Hopkins group, led by Dr. Jonathan M. Samet, chairman of 
epidemiology at the public health school there.

As part of a continuing effort to check for flaws, those scientists 
in recent weeks used a new method to look at their figures and 
obtained different results. They re-examined the original figures and 
found that the problem lay with how they used off-the-shelf 
statistical software to identify telltale patterns that are somewhat 
akin to ripples from a particular rock tossed into a wavy sea. 
Instead of adjusting the program to the circumstances that they were 
studying, they used standard default settings for some calculations. 
That move apparently introduced a bias in the results, the team says 
in the papers on the Web.

The chairman of the Johns Hopkins biostatistics department, Dr. Scott 
L. Zeger, said other researchers who used the software, S-Plus, 
should check for similar problems. It is widely used for research in 
fields like pharmacology, genetics, molecular biology and 
stock-market forecasting, as well as serving as a mainstay of other 
environmental studies.

Dr. Zeger and Mr. Greenbaum stressed that the new findings did not 
overturn the basic link between soot and illness. They also pointed 
to the recent publication of other studies on the long-term effects 
of soot that do not use the same analytical tools.

Still, industry officials said the new findings called into question 
the validity of some research underlying the new federal standards.

"This study is really one of the ones creating the path for the 
future on air-quality regulation," said Allen Schaeffer, executive 
director of the Diesel Technology Forum.

The new results, Mr. Schaeffer said, show that "particle science is 
still evolving, and so are the analytical tools to look at it."

Scientists involved with the soot standard said that there was much 
other evidence that pointed to the dangers of soot but that the 
errors in the Johns Hopkins work were still significant.

"It certainly brings into question the precision of the data," said 
Dr. Jane Q. Koenig, a professor of environmental health at the 
University of Washington and a consultant involved with the soot 
review. "That's very unfortunate, because this research was supposed 
to be the re-analysis that was going to give us a lot of confidence."

Senior government officials, including Dr. John D. Graham, President 
Bush's chief overseer of regulatory effectiveness at the Office of 
Management and Budget, said they had been told of the problems with 
the studies. Dr. Graham, who has often questioned the need for some 
rules, said that the apparent errors would "reduce significantly some 
benefit estimates fo reducing fine-particle pollution, but they do 
not call into question any of the key cause-effect relationships 
between pollution and premature death."

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