This wine argument is mostly hypothetical. It can run plenty of programs with the disable in place. I know because I've used it since the change.
See the following: http://web.archive.org/web/20150324113601/http://wiki.winehq.org/PreloaderPageZeroProblem On Mon, Dec 26, 2016 at 09:22:29PM +0000, David Laight wrote: > ISTR that wine is actually mapping 'everywhere' in order to ensure > the addresses it needs later can be made available by unmapping > specific ranges.
