So, I'm following up my own question.

The current answer that solves the current problem is to set swappiness to 
0.  Basically, in this environment, if any of Oracle's data space gets 
swapped out in preference to filesystem cache, there is a positive 
feedback with the application that causes everything to melt down.

Unfortunately, the DBAs are highly resistant to trying things like Huge 
Pages or ASM, so the fixes need to happen on the OS side.

-- Matt
It's not what I know that counts.
It's what I can remember in time to use.
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