Yes.
PDF do not flow text, which makes it hard to read in mobile phones. PDFs are 
not easily annotable. The solutions for annotating PDF either permanently 
modifies the file or keeps the annotations tied to that software which might 
not be available cross platform. Epub annotations follow the same story. 

TiddlyWiki allows you to annotate the book and avail annotations in all 
browsers.

 Of all the purposes TiddlyWiki is proposed to be suited for, ebooks and 
documentation is the best IMO

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