On Sun, 14 Mar 2004, Shearon, Tim went:

> I think that the more likely correct factors (you did reference
> them) in "withdrawal" symptoms to antidepressants are the
> metabolically factors. The timing for up or down regulation is
> simply too long (4 - 6 weeks is more like it) and too subtle to
> explain withdrawal symptoms as they are most frequently reported.

I don't think that's necessarily so.  It may take several weeks for
your SSRI to bring about certain up- or downregulations, but once
they've occurred, if you abruptly discontinue the SSRI and thereby
remove its acute effects, you're going to _unmask_ the effects of the
up- or downregulations, and that unmasking will start quickly.  This
is especially likely for SSRIs with short half-lives such as Paxil.

--David

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