Re: Withdrawal from antidepressants

[Dr . Bob Wildblood]

In my experience with "withdrawal" after the use of antidepressants, it 
has usually been when the patient decided to discontinue the medication 
and stops taking it "cold turkey."  Just as it takes some time (it is 
now thought that for some people it may be up to 3 months) to take 
effect, it also takes time to titrate the patient off of the 
medication.
On Mar 14, 2004, at 17:25, Shearon, Tim wrote:

Carol and others- I also think you got close to the answer (see other 
correction re- plasticity vs up- down- regulation). However, I think 
that the more likely correct factors (you did reference them) in 
"withdrawal" symptoms to antidepressants are the metabolically 
factors. The timing for up or down regulation is simply too long (4 - 
6 weeks is more like it) and too subtle to explain withdrawal symptoms 
as they are most frequently reported. For example, the hepatic, renal, 
hematological and other genetic/metabolic processes adapting to the 
withdrawal of the medication are far more likely culprits (if I'm 
reasoning correctly-
Dr. Bob Wildlbood
Lecturer in Psychology
Indiana University Kokomo
Kokomo, IN  56904-9003
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