Sorry I could not find the orginal source but the following is related dealing
with the paradoxial release of three neurotransmitters at the same time.
>>>>>>>>>>>
"Two distinct pools of synaptic vesicles appear to be involved in the
spontaneous release of neurotransmitters and in neurotransmission triggered by
a stimulus, researchers report in Neuron this week. Their findings raise
questions about a fundamental theory of neurotransmission developed by Bernard
Katz. "
"According to Levitan and Kaczmarek (The Neuron, 3rd Ed, Oxford,
2002, p. 250):
There is now convincing histochemical evidence that some
neurons contain one or more neuropeptides and a classical
neurotransmitter, packaged in different vesicles but often present
in the same synaptic terminal. ... In several cases it has been
been found that only the classical transmitter is released by
low-frequency stimulation, and corelease of the peptide
requires short bursts of high-frequency stimulation. ... The
coexistence of different neurotransmitters in distinct vesicle
populations within a single neuron allows that neuron to
produce different effects on a postsynaptic target, depending
on the precise pattern of stimulation."
Ron Blue
LCCC
[EMAIL PROTECTED]
---
