Any procedure since the advent of IRB's would require rescuing the subject.
These days you couldn't even drown a goldfish!

On Mar 4, 2009, at 5:27 PM, William Scott wrote:

There is another form of the forced swimming test which is a better indicator of the development of "hopelessness". Rats are sequentially exposed to regular increases in forced swimming time until the next trial will be beyond their endurance. At that point they don't swim and "give up". If an antidepressant has an effect on such hopelessness, it will extend the number of trials before the rat gives up. As far as I know, the procedure calls for rescuing the rat. I forget the name of this procedure, if there is one, but I imagine this is what Wittenborn is referring to.

Paul Brandon
Emeritus Professor of Psychology
Minnesota State University, Mankato
[email protected]


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