Hi

I actually use the PKU example as well to address the perceived immutability of 
genetically determined characteristics.  As to my admittedly cryptic phrasing, 
I was referring to the immutability of the genetic influence on the manifested 
characteristic, as elaborated by Stephen.  If I can quote a more credible 
source than myself for my wording, Plomin writes:

"The example of PKU serves as an antidote to the mistaken notion that genetics 
implies immutability, as discussed later."

For the article go to

http://www.uth.tmc.edu/clinicalneuro/institute/2005/Mazzocco's%20pdf's/Plomin%20Walker.pdf

Take care
Jim


James M. Clark
Professor of Psychology
204-786-9757
204-774-4134 Fax
[email protected]
 
Department of Psychology
University of Winnipeg
Winnipeg, Manitoba
R3B 2E9
CANADA


>>> <[email protected]> 18-Dec-09 12:46 PM >>>
On 17 Dec 2009 at 22:15, Jim Clark wrote:
> It also allows one to make the point that genetic does NOT
> equal immutable, perhaps another factor in student resistance to genetic 
> hypotheses. 

I must demur, although perhaps only to the way this is 
expressed. Genetic causation does mean immutable. It is 
possible  to reduce or prevent the secondary consequences of 
the genetic specification (a trivial example would be hair dye for 
people suffering from red hair; a non-trivial example the special 
diet used to treat PKU) but the genetic basis remains 
unchanged. It's still red under the blonde hair dye; the individual 
with PKU still can't metabolize phenylalanine. 

It is true that we are on the cusp of real genetic change through 
gene therapy; it may already be here in a few extraordinary  
cases. But in general, while we can ameliorate the 
consequences of a genetic specification, we cannot change the 
specification nor its direct consequence.

Cautious note to the red-haired. I joke. I have nothing against 
red hair. Indeed, some of my best friends have red hair. 

Stephen

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Stephen L. Black, Ph.D.          
Professor of Psychology, Emeritus   
Bishop's University               
 e-mail:  [email protected] 
2600 College St.
Sherbrooke QC  J1M 1Z7
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